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Allie
On July , , I rang a bell in the lobby of the Cincinnati Children's Hospital that signified the end of my chemotherapy treatments and the beginning of…
Keisha
In , I was diagnosed with a rare and chronic form of lymphoma (NHL). I was beyond devastated as I knew there was no cure for my condition, and I also…
Avery
When I was a senior in high school, my life changed forever. In my senior year, playing my last season of basketball and gearing up to play college so…
Living with NHL
Keaton
I was diagnosed with Hodgkin lymphoma (HL) in May of . I first noticed something was wrong in January of that year when I noticed lumps in my neck. I …
Jelien
Jelien started showing signs in early July of . She had bruises and cuts that were taking too long to heal. In November, she kept spiking fevers with …
Zariyah
Zariyah was diagnosed with acute lymphoblastic leukemia (ALL) on May , . She had just turned three years old the previous November. She was immediatel…
Christopher Porter
Dr. Porter is an Associate Professor of Pediatrics and holds the Paul Amos Chair for Pediatric Oncology Research. He is a pediatric and directs a lab…
Targeting Siglec15 to promote immune response to malignant B cells
The goal of this project is to explore a novel immunologic therapeutic target for hematologic malignancies, SIGLEC15 (Sig15). The central hypothesis i…
Investigating anti-neoplastic effects of beta blockers in multiple myeloma
Multiple myeloma (MM) relies on the bone marrow (BM) niche to progress to refractory disease. We found that beta blockers alter BM niche elements fost…
Alana
My name is Alana, and I’m years old. Here is my story. On June , , I was out having dinner with my family, and my smartwatch told me that my heart ra…
Targeted combination therapies for leukemia with NUP98 translocations
Leukemia patients with chromosomal translocations of the Nucleoporin (NUP98) gene suffer from very poor prognosis. In this project we will identify ne…
Joachim Yahalom
MD- Hebrew University, Jerusalem. Residencies and Fellowships in Clinical and radiation Oncology in Israel and Memorial . Armored Brigade Physician (M…
Impact of sublethal radiation dose on tumor response, microenvironment and the immune system
Extremely low dose radiation can improve blood cancer outcomes. But the mechanisms of how sublethal radiation (SRT) affects tumors, the microenvironme…
Suzanne Lentzsch
I’m a Professor of Medicine and the Director of the Multiple Myeloma and Amyloidosis Program at Columbia University. I received my medical and doctora…
Targeting the MMP-13/PD-1H signaling axis for multiple myeloma bone disease and immunosuppression
Multiple myeloma is an incurable blood cancer complicated by bone diseases and compromised immune system. Our work indicated that checkpoint inhibitor…
Identification and Molecular Analysis of Pre-Myelofibrotic Stem Cells
Myelofibrosis is a severe myeloproliferative neoplasm with no known cure. We have obtained unique insights into the underlying mechanisms responsible …
LLS is Committed to Advocating for Cancer Patients in Wake of Dobbs Ruling
LLS Remains Committed to Advocating for Cancer Patients in Wake of Dobbs Ruling
Advocacy
Jane Oliaro
Professor Jane Oliaro is an internationally recognized cancer immunologist motivated to translate scientific discoveries into the clinic.
Improving CAR-T cell therapy outcomes for patients with for aggressive lymphoma and multiple myeloma
Despite the promise of cell immunotherapy for patients with lymphoma and multiple myeloma, a significant proportion of patients fail to respond or re…
Richard Lock
Dr. Lock is investigating mechanisms of glucocorticoid resistance in pediatric acute lymphoblastic leukemia (ALL) and tests potential new treatments f…
Therapeutic targeting of T-cell acute lymphoblastic leukemia using an AKR1C3-activated prodrug
acute lymphoblastic leukemia () is an aggressive malignancy that is exceptionally difficult to cure after relapse. We have previously shown that expr…
Kirk Schultz
Dr. Kirk Schultz is a Professor at the University of British Columbia, BC Children’s Hospital Research Institute, and an elected fellow of the Canadia…
A Polyomic Approach to Chronic Graft-versus-Host Disease (cGvHD) Biomarkers in Adults
Our team is the first to develop a polyomic pediatric cGvHD biomarker test for assessing the risk of developing cGvHD. A cooperative adult phase III c…
Marco Ruella
Dr. Marco Ruella is a and assistant professor at the University of Pennsylvania. He treats patients with blood cancers and focuses on using immunothe…
A First-in-human Clinical Trial of CD5 knocked-out Chimeric Antigen T Cells for T-cell Lymphomas
This proposal seeks to develop for the first time in humans a novel CD5 knocked out (KO) chimeric antigen receptor T cell (CART) product for patients…