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Genetic pathways of myeloid transformation and treatment response
Our central goal is to improve clinical outcomes in patients with myeloid malignancies through developing an enhanced mechanistic understanding of dis…
Julia Maxson
Dr. Maxson is an assistant professor in the Knight Cancer Institute, where she investigates the cellular and molecular changes that cause myeloid leuk…
Targeting the interplay between signaling and transcriptional dysfunction in myeloid leukemias
Our research program is focused on understanding the intersection between signaling and transcriptional dysfunction in myeloid leukemias. We leverage …
Yibin Yang
I completed my Ph.D. training with Dr. Michelle Kelliher at the University of Massachusetts Medical School, studying the signal transduction pathways…
Analysis and therapeutic targeting of the immune regulatory and ubiquitination pathways in Anaplastic Large Cell Lymphoma and Hodgkin Lymphoma
My lab is focused on the immune regulatory mechanisms and machinery in lymphoma. We have established multiple screening technologies and animal mode…
Genomic interrogation of high-risk myeloid neoplasms to identify new therapies
The goal of my research program is to improve the outcomes for patients with myeloid blood cancers, particularly those with loss of chromosome or C…
Megan McNerney
Dr. Megan McNerney, MD/PhD, is an Associate Professor in the Departments of Pathology and Pediatrics at The University of Chicago. She is a cancer gen…
Daniel Herranz
A PharmD by training, I then obtained my PhD guided by Dr. Manuel Serrano at the CNIO studying Sirt1 role in metabolism and cancer, which led to and…
Therapeutic exploitation of novel mouse models and metabolic interventions in leukemia
Our research program aims to gain a deeper understanding of the pathobiology of and HSTL.To this end, we will use novel mouse models, techniques and…
Investigating and targeting the histone acetylation reader protein ENL in acute leukemias
Leukemia often results from aberrant gene expression caused by epigenetic alterations. Previously we discovered a novel histone acetylation reader dom…
Hong Wen
I am an Associate Professor in the Department of Epigenetics at Van Andel Institute. My research is focused on epigenetic regulation of gene expressio…
A Phase I/II Study of the Combination of ALX148, Rituximab and Lenalidomide in Patients with Indolent and Aggressive B-cell Non-Hodgkin Lymphoma
SIRPα+ macrophages mediate resistance to lenalidomide in lymphoma, limiting the activity of immunotherapy for these patients. Therefore, we propose a…
Cruz
Cancer almost killed me, but more importantly, it made me who I am and who I will become. I was diagnosed with acute myeloid leukemia (AML) at Texas C…
Nicolas Nassar
I am an Assistant Professor at Cincinnati Children's Hospital Medical Center. My areas of research interest include drug development and signaling wit…
Overcoming RAS-driven Mechanisms of Resistance in Leukemia
The protein kinase (MAPK) pathway is activated in leukemia and is a hallmark of resistance to therapies. This project uses xenograft models of rela…
Suman Paul
I am an assistant professor of oncology at the Johns Hopkins School of Medicine where I treat patients suffering from leukemias and lymphomas. In my c…
TCR-directed immunotoxins and antibody drug conjugates for the treatment of T cell malignancies
Few treatment options are available for T cell leukemias and lymphomas, collectively called T cell cancers that affect ~, patients worldwide each year…
Niclosamide for the Treatment of Relapsed/Refractory Pediatric Acute Myeloid Leukemia
Niclosamide is an FDA approved drug that is well tolerated and acts synergistically with chemotherapy to kill AML cells. We will conduct a Phase I cl…
How One Powerful Philanthropic Competition is Taking the Fight Against Cancer by Storm
How One Powerful Philanthropic Competition is Taking the Fight Against Cancer by Storm
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Manuales
Manuales del sobreviviente Utilice estos Manuales del sobreviviente para recopilar toda la información importante que necesite a lo largo de las etap…
LLS Invests in Solutions to Advance Health Equity
More than $. million awarded through new LLS Equity in Access Research Program
Suggested Reading You Are So Much More
You Are So Much More: An Inspiration for Children Healing From Illness or Injury by Serena Tejpar Publisher: Loving Healing Press June , , Paperback…
Coffee With LLS: Let’s Talk About COVID
Please note, with the fast developing knowledge on this topic, some recommendations may change as new data emerges. Click here to access the latest LL…
John
After six months of frequent hospital and doctor visits for unexplained fever, weakness, and changes in John's activity and personality, an ultimatum …
Cathy
I decided to call my cancer the “little c” rather than the “Big C.” I wasn't giving it that much power over my life!The year was memorable for all th…