Who We Fund

Columbia University Medical Center

I’m a Research Scientist at Columbia University Multiple Myeloma Program. I have over 20 years of research experience, especially with profound expertise in pharmaceutical biochemistry and drug development in multiple myeloma. I received my Ph.D. degree in Pharmacology and Chemistry of Peptides in 2005. After that, I did my postdoctoral training at the University of Pittsburgh Cancer Institute and have focused on multiple myeloma drug development since then. My current research aims to identify the druggable targets and develop therapeutic approaches for relapsed/refractory multiple myeloma-carrying RAS mutation. My work has been awarded by the International Myeloma Foundation Brian D. Novis Research Grant, the International Myeloma Society, and the Paula and Rodger Riney Foundation Translational Research Award. My research has also resulted in over 18 peer-reviewed articles in top journals such as JCI, Blood, and Leukemia.

Program Name(s)

Translational Research Program

Project Title

Targeting GCK as a novel and selective therapeutic strategy against RAS mutated Multiple Myeloma

Johns Hopkins University

As a physician-scientist in the Division of Hematologic Malignancies at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Dr. Dalton has a clinical specialty in myeloid leukemias and a research laboratory that focuses on the study of DNA mutations that drive those leukemias. In particular, he is working to better understand DNA mutations in the spliceosome, which occur in many patients with MDS and AML and are currently difficult to treat. He uses bone marrow and blood samples generously donated by patients, together with cell ‘models’ that he genetically engineers in the lab, to understand what these DNA mutations do and how they might be targeted with new treatments. His work has led to identification of vulnerabilities in cells containing these mutations that he aims to translate into novel therapeutic approaches in MDS and AML.

Program Name(s)

Translational Research Program

Project Title

Therapeutic modulation of serine availability for SF3B1-mutant myeloid malignancies

Dana-Farber Cancer Institute

Dr. Stahl is a member of the Adult Leukemia Group at Dana-Farber Cancer Institute and an Instructor of Medicine at Harvard Medical School. His research focus is on early phase clinical trials in myeloid malignancies including acute myeloid leukemia and myelodysplastic syndromes. He authored and co-authored more than 70 peer reviewed publications and has presented his research in multiple national and international meetings. He received the ASCO Conquer Cancer Foundation Young Investigator Award, the ASH HONORS Award and several abstract achievement awards. He is a member of the Editorial Board of Leukemia & Lymphoma and serves as a reviewer for several journals including Blood, Blood Advances and Clinical Cancer Research. He graduated from Hannover Medical School in Germany and completed his internal medicine residency and chief residency at Yale School of Medicine and his Hematology and Oncology fellowship at Memorial Sloan Kettering Cancer Center.

Program Name(s)

Translational Research Program

Project Title

Memory-like natural killer cells and venetoclax to eradicate measurable residual disease in AML

Perelman School of Medicine at the University of Pennsylvania

Dr. Liling Wan is an Assistant Professor at the University of Pennsylvania. She received a B.S. in Biological Sciences and Biotechnology from Tsinghua University and a Ph.D. in Molecular Biology from Princeton University. She conducted postdoctoral research at Rockefeller University where she studied chromatin regulators in cancer. The Wan lab studies basic gene regulatory mechanisms and how these mechanisms are dysregulated in cancer, with the goal of harnessing these insights for therapeutics. Her research has revealed how chromatin “reader” proteins impact gene regulation in cancer such as acute myeloid leukemia and led to early drug development efforts targeting these mechanisms. Dr. Wan has been recognized for her innovative and impactful research through numerous awards including AACR NextGen Star, NIH Pathway to Independence Award, the NIH Director’s New Innovator Award, and was recently named a Pew-Stewart Scholar, V Foundation Scholar, and ASH Scholar.

Program Name(s)

Career Development Program

Project Title

Epigenetic Mechanisms in Acute Myeloid Leukemia

Albert Einstein College of Medicine

Dr. Will has been a group leader at the Albert Einstein College of Medicine since 2016. She obtained her Ph.D. in Cell Biology from the University of Freiburg, Germany and underwent further training in hematology/oncology with Dr. Ulrich Steidl. With a passion for and through the lens of stem cell biology, Britta’s laboratory seeks to discover novel therapeutic options for patients with myeloid malignancies. Current research concentrates on two largely uncharted territories in blood stem cell aging and leukemic stem cell maintenance - iron homeostasis and highly selective autophagy. Dr. Will also serves as co-leader of the Stem Cell and Cancer Biology Program and directs the Cancer Stem Cell Pharmacodynamics Unit at the NCI-designated Montefiore-Einstein Cancer Center. She is the recipient of prestigious young investigator awards, including from the Pershing Square Sohn Cancer Research Alliance, Gilead, AAMDSIF, Feldstein Medical Foundation, and the Leukemia Research Foundation.

Program Name(s)

Career Development Program

Project Title

Therapeutically actionable molecular safeguards in leukemic stem cells

Indiana University

Dr. Yan Liu received his PhD degree in Molecular Biology from the Chinese Academy of Sciences. Yan completed his postdoctoral training in hematology in the laboratory of Dr. Stephen Nimer at the Memorial Sloan Kettering Cancer Center (MSKCC). Dr. Liu joined Indiana University School of Medicine as an Assistant Professor in 2010 and was promoted to Associate Professor in 2016. Currently, Dr. Liu is an Associate Professor at the Northwestern University Feinberg School of Medicine. Dr. Liu is the Co-leader of the Hematologic Malignancies Program at the Robert H. Lurie Comprehensive Cancer Center. The Liu laboratory investigates the molecular mechanisms underlying hematopoietic stem cell (HSC) aging and pathogenesis of clonal hematopoiesis of indeterminate potential (CHIP), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). The goal of this Translational Research Program award is to understand the pathogenesis of MDS and develop novel therapeutic approaches to improve MDS treatment.

Program Name(s)

Translational Research Program

Project Title

Development of therapeutic strategy for the treatment of MDS

Washington University in St. Louis

Stephen Oh, MD, PhD is Associate Professor of Medicine in the Division of Hematology at Washington University School of Medicine. Dr. Oh’s clinical and laboratory research efforts are focused on myeloproliferative neoplasms (MPNs). His group employs patient samples and animal models to investigate fundamental mechanisms driving the initiation, development, and progression of MPNs. A major focus of the laboratory is to utilize mass cytometry and multiplex imaging approaches to interrogate dysregulated cytokine signaling networks in MPNs. Dr. Oh has extensive clinical experience in the diagnosis and management of MPN patients and has contributed to numerous clinical trials investigating novel targeted therapies for MPN patients. The long-term objective of his work is to translate the findings from his laboratory research into improved therapies for MPN patients.

Program Name(s)

Translational Research Program

Project Title

Leveraging dysregulated signaling networks for therapeutic benefit in myeloproliferative neoplasms

University of Michigan

Dr. Jolanta Grembecka is an Associate Professor in the Department of Pathology, University of Michigan. Dr. Grembecka’s research is focused on development of small molecule inhibitors of proteins involved in leukemogenesis. Her laboratory has developed the first small molecule inhibitors of the menin-MLL1 interaction as a treatment for acute leukemia, which were advanced to clinical studies in acute myeloid leukemia patients. Her laboratory is also developing new targeted therapies for hematologic cancers by blocking novel epigenetic targets, including ASH1L histone methyltransferase.

Dr. Grembecka has received PhD in Chemistry at Wroclaw University of Technology, Poland. She completed postdoctoral training in drug discovery at the University of Virginia and in 2009 started her independent position at the University of Michigan. Dr. Grembecka is a co-author on over 80 scientific publications and an inventor on 15 patents. She is LLS Scholar and ACS Research Scholar recipient.

Program Name(s)

Translational Research Program

Project Title

ASH1L degradation as a new treatment for acute leukemia

Targeted combination therapies for leukemia with NUP98 translocations

The University of Alabama at Birmingham

Dr. Goyal obtained his medical school diploma from Smt. N.H.L. Municipal Medical College in Ahmedabad, India, in 2011 and moved to the US to complete a residency in Internal Medicine from Creighton University Medical Center, Omaha, Nebraska in 2016. He pursued a fellowship in hematology-oncology from Mayo Clinic, Rochester, Minnesota from 2016-2019. He developed a unique focus in histiocytic neoplasms, including Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. He conducted multiple studies describing the epidemiology, treatments, and outcomes of patients with histiocytosis and led to the establishment of first of its kind multidisciplinary Histiocytosis Working Group. He has led national and international guidelines on the diagnosis and management of these rare disease entities. He was subsequently recruited to join the Hematology-Oncology division at University of Alabama at Birmingham as an Assistant Professor in 2019 where he launched the Histiocytic Disorder Survivor Study to assess long-term outcomes among individuals with histiocytic neoplasms.

Program Name(s)

Special Grants

Project Title

A Multi-Center, Multi-National Investigation of Survivorship and Patient-Reported Symptoms in Erdheim-Chester Disease

UNC Lineberger Comprehensive Cancer Center

I am a first-generation college graduate with a Master’s degree in Chemistry and Ph.D. in Biochemistry. My long-term career goal is to lead my own research group focused on understanding key immunological pathways by which the human body fights infection and to develop effective therapies that target blood cancers. During my research career thus far, I have gained a unique repertoire with expertise in chemical biology, biochemistry, and molecular biology with broad knowledge in immunology, cancer biology, and virology. Currently, I am training at the University of North Carolina's Lineberger Comprehensive Cancer Center under the mentorship of Blossom Damania who is a leader in the fields of viral oncogenesis and viral immunology. As many people have had the misfortune of personal or family experience with blood cancers, myself included, I am devoted to advancing my training and progressing research in this field to help alleviate the burden of these diseases.

Program Name(s)

Career Development Program

Project Title

Elucidating the role of FAM72A in EBV-driven B cell lymphomagenesis

University of California San Diego

Dr. Su is Professor of Obstetrics, Gynecology and Reproductive Science in the Division of Reproductive Endocrinology and Infertility at the University of California, San Diego, where she directs the Oncofertility Program. Dr. Su completed residency in obstetrics and gynecology, fellowship in reproductive endocrinology, and Master’s of Science in Clinical Epidemiology at the University of Pennsylvania, as well as implementation science training through NCI’s Training in Dissemination and Implementation Research in Cancer Program. Dr. Su is a physician scientist who conducts patient oriented research on reproductive health in young cancer survivors. Through innovative observational and interventional studies, team-based science, and community engagement, Dr. Su’s studies focus on estimating reproductive risks after cancer, implementing evidence-based practices, and improving equity in reproductive health care delivery, funded by NCI, NICHD, American Cancer Society, and Robert Wood Johnson Foundation. Recent work on health policies as an intervention to improve access to care suggest that state-level fertility preservation benefit mandates are not working as intended. This team with existing collaborations and complementary methodologic and clinical expertise will use national administrative data to estimate the impact of mandated insurance benefits on fertility preservation utilization and affordability, in order to inform future federal and state laws and regulations.

Program Name(s)

Equity in Access

Project Title

Impact of State Health Insurance Mandates on Affordability and Utilization of Fertility Preservation in Adolescent and Young Adults with Blood Cancers

Institute of Biomedical Research from Salamanca

Noemi Puig, MD, PhD earned her medical degree from the Universidad Complutense in Madrid and she completed her residency in Internal Medicine and Hematology at the University Hospital La Fe in Valencia, Spain. She completed a 3-year fellowship in Lymphoma, Myeloma and Autologous Stem Cell Transplantation at the Princess Margaret Hospital in the University of Toronto, in Toronto, Canada. She earned a doctoral degree at the Medicine Department of the University of Salamanca, in Spain, with a thesis entitled “Optimization and Critical Analysis of Minimal Residual Disease Monitoring with ASO RQ-PCR in Patients with Multiple Myeloma and Comparison with Multiparameter Flow Cytometry”. Dr. Puig currently serves as a Consultant Physician at the Hematology Department in the University Hospital of Salamanca. She also works in the Flow Cytometry Laboratory of the University Hospital of Salamanca, where she is responsible for the studies developed by the Spanish Myeloma Group.

Dr. Puig is a member of the Programa para el Estudio de la Terapéutica en Hemopatías Malignas (PETHEMA) and the Spanish Myeloma Group (GEM) as well as of the EuroFlow Group.

Dr. Puig´s main research interests include the role of multiparameter flow cytometry and of mass spectrometry in diagnosis, risk stratification and minimal residual disease monitoring in patients with monoclonal gammopathies. She is an author or co-author in several research articles, reviews and book chapters.

Program Name(s)

Translational Research Program

Project Title

Peripheral blood-based disease monitoring by mass spectrometry in patients with multiple myeloma