Who We Fund

The Ohio State University

Ann-Kathrin Eisfeld is a Tenure-track Assistant Professor and physician-scientist whose research focuses on acute myeloid leukemia genetics, as well as age-, gender- and race-associated differences in mutational landscape and prognostic significance of molecular markers. Her studies aim to identify prognostic factors and lead to refinements of disease classification and molecular subtypes, to enable personalized risk-stratification and treatment options. Dr. Eisfeld serves as director of the Clara D. Bloomfield Center for Leukemia Outcomes Research at The Ohio State University, which leads large-scale AML correlative studies directed at discovering associations between patient outcomes, genetic/genomic features, and clinical/demographic characteristics. The Center is dedicated to the long-term friend and mentor of countless Leukemia researchers and clinicians, Clara Bloomfield, and was established in 2020 to carry on her legacy of molecular prognostic association studies in AML and other hematologic malignancies.

Program Name(s)

Translational Research Program

Project Title

Improving the outcomes of young Black adults diagnosed with acute myeloid leukemia

The Regents of the University of California, San Francisco

I am a postdoctoral researcher at UCSF, aiming to advance proteomic technologies for target discovery and redefine immunotherapy in blood cancers. In Dr. Arun Wiita's lab, I focus on identifying novel surface antigens in hematological malignancies like AML and multiple myeloma. By combining proteomics with immunotherapy strategies, I aim to bridge scientific discovery and clinical applications, improving outcomes for patients. My PhD in clinical proteomics from IIT-Bombay provided a foundation in biomarker discovery and translational research. I specialize in mass spectrometry-based proteomics, applying quantitative and targeted approaches to explore cancer proteomes and identify "proteoforms" as therapeutic targets. Building on promising data, my research explores surface protein post-translational modifications as a new class of immunotherapy targets, positioning me to become an independent investigator developing breakthrough therapies for blood cancers.

Program Name(s)

Career Development Program

Project Title

“Open-Surfaceomics” for Identifying Novel Surface PTMs as Immunotherapy Targets in AML

University of British Columbia

Dr. Kirk Schultz is a Professor at the University of British Columbia, BC Children’s Hospital Research Institute, and an elected fellow of the Canadian Academy of Health Sciences. Dr. Schultz is a Pediatric Hematologist/Oncologist focused on new therapies and rejection in Blood and Marrow Transplantation (BMT) and immune therapy of blood cancers. Dr. Schultz is a past recipient of the CIHR/Wyeth Clinical Research Chair in Transplantation, past chair of the Pediatric BMT Consortium the largest children’s BMT clinical trials group world-wide, and president-elect of Cell Therapy and Transplantation Canada (CTTC), the national group for Canadian cell therapy and BMT. Dr. Schultz was the co-chair of the 2020 NIH cGvHD Consensus meeting and past chair of the Biomarkers working group for the previous 2 Consensus meetings (2004 & 2014). Dr. Schultz was the Team leader for the pediatric Applied Biomarkers in Late Effects (ABLE) Team grant (2011 – 2016; $4.3M Canadian Institutes of Health Research (CIHR) funded). Dr. Schultz has 219 publications and 2 CIHR Grants and other smaller funding.

Program Name(s)

Translational Research Program

Project Title

A Polyomic Approach to Chronic Graft-versus-Host Disease (cGvHD) Biomarkers in Adults

Dana-Farber Cancer Institute

Dr. Lindsley is an Assistant Professor of Medicine at Harvard Medical School and Dana-Farber Cancer Institute. He received his M.D. and Ph.D. in Immunology from Washington University School of Medicine, then completed a residency in internal medicine at Brigham and Women’s Hospital and a fellowship in oncology at the Dana-Farber Cancer Institute. He is a member of the MDS Genetics Subcommittee for the NIH National MDS Study, NHLBI Trans-Omics for Precision Medicine Steering Committee, and the International Working Group for Prognosis in MDS (IWG-PM) molecular committee. The primary focus of his laboratory is the biology and treatment of myeloid malignancies. His genetic studies have led to new genomic models of leukemia classification and MDS outcome after stem cell transplantation. His laboratory uses mouse and cell line models to dissect the mechanistic basis of genetic cooperation during myeloid disease progression, with a specific focus on leukemia initiation in patients with predisposition syndromes and mutations that cause epigenetic alterations.

Program Name(s)

Career Development Program

Project Title

Genetic pathways of myeloid transformation and treatment response

Memorial Sloan Kettering Cancer Center

I am a clinical-translational researcher focusing on new treatments for lymphomas with a particular focus on T-cell/cutaneous lymphomas. Since entering the field of hematology/oncology, I have been drawn to the study of lymphoma and the care of patients facing lymphoma given how varied these conditions are and the major unmet needs that exist. In my clinical practice, I see patients and caregivers navigating these diseases, treatments, and side effects, and this stimulates me to pursue advancements in my research endeavors. My overarching goals are to bridge laboratory investigations with work done in clinical trials towards ultimately improving and refining our therapeutic approaches for these challenging diseases.

Program Name(s)

Academic Clinical Trials Program (ACT)

Project Title

Targeting mutant IDH2 in angioimmunoblastic T-cell lymphoma

Houston Methodist Research Institute

I am a translational tumor immunologist. I have 30 years of experience as a well-funded and published researcher and am one of the leading investigators in the fields of tumor immunology in myeloma and other cancers. My laboratory has been working on: (1) characterizing myeloma- and tumor-specific T cells and their subsets and examining their functions, (2) identifying novel myeloma-associated antigens and better methods for immunotherapy, (3) investigating the cross-talk between the tumor microenvironment (TME) and immune system, (4) conducting clinical trials to evaluate the efficacy of immunizing patients with idiotype or dendritic cell-based vaccines, and (5) exploring immunotherapies using myeloma antigens such as DKK1. Our recent research focuses on: (a) developing novel therapeutic mAbs and CAR-T cells for cancers, (b) identifying T-cell subsets that have potent antitumor effects after adoptive transfer, and (c) identifying TME components that induce tumor drug resistance.

Program Name(s)

Translational Research Program

Project Title

Developing Novel CAR-T Cell Therapy For Hematologic Malignancies

Dana-Farber Cancer Institute

Dr. Odejide is a health services researcher, a hematologic oncologist at the Dana-Farber Cancer Institute, and an Assistant Professor of Medicine at Harvard Medical School. Her research aims to improve outcomes and care delivery for patients with blood cancers throughout their disease trajectory. A substantial proportion of her work has focused on improving end-of-life (EOL) care for this patient population. For example, her work demonstrated that EOL quality measures developed for patients with solid malignancies are also applicable for patients with blood cancers (JCO, 2016). She also has extensive experience using insurance claims-based data (Medicare and Private) to identify potential solutions to improve EOL care. Dr. Odejide is interested in translating her work to impact policy. For example, she synthesized findings from her research and that of others to propose potential policy solutions to reduce barriers to high-quality EOL care for patients with blood cancers (JAMA, 2016). Her research was also part of the body of work used to support the American Society of Hematology 2019 policy statement to address barriers to high-quality hospice services for patients with blood cancers.

Program Name(s)

Equity in Access

Project Title

Health Insurance and End-of-Life Care for People with Hematologic Malignancies

Emory University

Dr. Porter is an Associate Professor of Pediatrics and holds the Paul Amos Chair for Pediatric Oncology Research. He is a pediatric hematologist-oncologist and directs a lab in which they study molecular and cellular mechanisms of leukemogenesis, with the goal of developing novel therapeutic strategies. Most recently, they have been studying how leukemia cells influence the microenvironment to promote immune evasion. For example, they found that IL-12 overcomes calcineurin-dependent immune evasion by leukemia cells. Collaboratively, they designed BiTEokines to deliver IL-12 to the immune synapse of T cells and leukemia cells, supported by a DOD award (CA180783). They have also found that B cell malignancies express high levels of Siglec15, a newly identified immune checkpoint, and that inhibition of Siglec15 promotes immune clearance of malignant B cells in vivo. Thus, they are uniquely positioned to further develop Siglec15 as a therapeutic target for leukemia and lymphoma.

Program Name(s)

Translational Research Program

Project Title

Targeting Siglec15 to promote immune response to malignant B cells

Stanford University

I am a physician-scientist and hematologist focused on clinical translation of T-cell biology. I received my MD from Kyushu University, and subsequently completed Residency Training at Toranomon Hospital, the largest transplant center in Japan. I continued my Hematology training at Kyushu University, where I qualified as a Board-certified specialist (2017) and supervisory hematologist (2021) by the Japanese Society of Hematology. For my PhD (2014-19), I studied expression profiles and histologic features of TCLs. I discovered distinct TCL clinical groups identified by infiltrating immune cell patterns in the microenvironment. Based on my dissertation work (Sugio, et al 2018 Blood Advances), I planned and conducted a Phase II trial of PD1 inhibition for relapsed/refractory TCL (UMIN000034499). In 2020, I received a JSPS fellowship to study the TCL microenvironment. I joined the Alizadeh lab at Stanford in 2021, where I am developing tools to analyze immune status using liquid biopsies.

Program Name(s)

Career Development Program

Project Title

An integrated liquid biopsy framework for surveillance of residual disease and host immune status of T-cell lymphomas

Washington University in St. Louis

Dr. Tyler Parsons completed his PhD research at Oakland University and the Beaumont Research Institute in the lab of Dr. Gerard Madlambayan where he published on the role of blood stem cells in tumor response to radiation therapy. During the final year of his PhD, he was diagnosed with a myeloproliferative neoplasm (MPN) which directed his career focus and passion to furthering the understanding of MPNs and their transformation potential to leukemia. To this end, he joined the lab of Dr. Grant Challen at Washington University School of Medicine (St. Louis) where he is investigating clonal evolution in MPNs and the mutational trajectory leading to secondary leukemia. The aim of his post-doctoral fellowship is to describe the clonal architecture of MPN disease progression to leukemia which could lead to early detection and improved disease surveillance. He is passionate about improving outcomes for patients by advancing our understanding of both the biology and disease evolution of MPNs.

Program Name(s)

Career Development Program

Project Title

Mechanisms of Clonal Evolution in the Transformation of MPN to sAML

TAP Partner

BioInvent International AB is a clinical-stage biotech company that discovers and develops novel and first-in-class immuno-modulatory antibodies for cancer therapy, with currently four drug candidates in five ongoing clinical programs in Phase 1/2 trials for the treatment of hematological cancer and solid tumors, respectively. The Company's validated, proprietary F.I.R.S.T™ technology platform identifies both targets and the antibodies that bind to them, generating many promising new drug candidates to fuel the Company's own clinical development pipeline and providing licensing and partnering opportunities.

Program Name(s)

Therapy Acceleration Program

Project Title

A phase 1/2 study of BI-1206, a monoclonal antibody to CD32b (FcyRIIB), in combination with rituximab in patients with indolent NHL that has relapsed or is refractory to rituximab

A phase 2 study of BI-1808, a monoclonal antibody to TNFR2, as a single agent and in combination with pembrolizumab in patients with solid tumors and CTCL

The University of Texas MD Anderson Cancer Center

Dr. V. Lokesh Battula received his Ph.D. from Justus Liebig University. He is currently working as a research faculty, Associate Professor, in the Department of Leukemia at MD Anderson Cancer Center. Dr. Battula’s research is focused on development of immune therapeutic tools for hematologic malignancies and solid tumors. He discovered ganglioside GD2 as a unique marker to identify cancer stem cells from primary breast tumors and cell lines. He is currently developing antibody based approaches for targeting GD2 in solid tumors. He is also interested in understanding the metabolic processes that regulate the expression of GD2 and the function of CSCs in primary tumors. His lab is working on antibody-based approaches for targeting immune checkpoint protein including B7-H3, CD47 and SIRPα in hematologic malignancies and solid tumors. These proteins play a crucial role in the inhibition of immune cells in primary tumors. He is developing therapeutic antibodies against immune checkpoint proteins that could be used in the treatment of cancer.

Program Name(s)

Translational Research Program

Project Title

Targeting immune checkpoint protein B7-H3 (CD276) in acute myeloid leukemia

Arming NK Cells to Target B7-H3+ AML Cells