1556 results for Leukemia
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Daniel
I was diagnosed with chronic lymphocytic leukemia (CLL) in March 2010 at the age of 48. The cancer advanced rapidly and I was treated with a fludarab…
Optimizing MICA/B antibody for AML by selective binding to Fc activating receptors
Acute myeloid leukemia (AML) is a blood cancer characterized by poor clinical outcomes. We developed an antibody that inhibits AML in models by trigge…
TCR directed immunotoxins and antibody drug conjugates for the treatment of T cell malignancies
Few treatment options are available for T cell leukemias and lymphomas, collectively called T cell cancers that affect ~100,000 patients worldwide eac…
Evaluating a novel collaboration between NOTCH1 and MLL1 for improved targeted treatments in T-ALL
Most T cell acute lymphoblastic leukemia (T-ALL) patients respond to chemotherapy, however many relapse with limited therapy options. To address this …
Targeting Enhancer Dysfunction in Hematological Malignancy
Blood cancers such as leukemia, lymphoma and myeloma may be caused by abnormal regulation of genes that control normal cell growth and development. Ge…
Leveraging dysregulated signaling networks for therapeutic benefit in myeloproliferative neoplasms
The objective of this project is to decipher mechanisms driving transformation of myeloproliferative neoplasms (MPNs) to secondary acute leukemia (sAM…
A novel BAFF CAR-T for treatment of HCL
Despite the success of Chimeric antigen receptor T cell (CAR-T) immunotherapies, disease relapse occurs in a majority of patients. We have developed a…
Uncovering mechanisms of DNMT3A stability in hematologic malignancies
DNMT3A is a critical tumor suppressor in hematologic malignancies; DNMT3A protein levels affect both tumor latency and type. DNMT3A is regulated in pa…
Mantle Cell Lymphoma Video Vignettes for Healthcare Professionals
Developed through a collaboration between The Leukemia & Lymphoma Society & The Association of Cancer Care Centers.This video series provides an overv…
Education Resources
Rick
Rick Ostroff and his family have a legacy of philanthropy with a heartfelt connection to a disease he never had. During the first three years of his l…
Allison
My story is not all that different from many others. It began with two-year-old me not feeling well and my mom taking me to the pediatrician on a Mond…
A multiantigen-targeting cytotoxic CD4+ T cell approach for treating B cell malignancies
B cell malignancies comprise a large number of different types of lymphomas and leukemia, which collectively represent the sixth leading cause of canc…
Targeting SF3B1 splicing factor mutant myeloid malignancies through dependency on GPATCH8
Mutations in RNA splicing factors, particularly those involving the core splicing factor SF3B1 are amongst the most common mutations found in myeloid …
American Society for Clinical Pathology (ASCP) Patient Champions
To empower patients, caregivers, and advocates through education and awareness about laboratory diagnostics, lab tests, and pathology follow-up care t…
Metabolic Regulation of Leukemic Cell Fate
Cell-intrinsic metabolic processes are dysregulated in acute myeloid leukemia (AML) and can act to sustain an oncogenic state of differentiation arres…
Investigating the role of preleukemia duration and clonal burden in progression to AML
The development of acute myeloid leukemia (AML) is preceded by a “preleukemic” phase in which mutated hematopoietic stem cells expand due to a fitness…
Deciphering the role of p53 signaling in NPM1-mutant AML
NPM1c and TP53 mutations are exclusive in acute myeloid leukemia (AML) despite both being commonly present in patients, suggesting a fitness disadvant…
Mechanisms of Clonal Evolution in the Transformation of MPN to sAML
This research will investigate blood stem cell mutations associated with progression of myeloproliferative neoplasm (MPN) to secondary acute myeloid l…
Ally
I was diagnosed with Hodgkin lymphoma (HL) in October 2024 and began chemotherapy (my last is April 25). My best friend and I were supposed to run a h…
Dare 2 Dream
Robert
I was diagnosed on August 28, 1999 with acute myeloid leukemia (AML). I was told at that time that I would not survive the next week.Well, at 28 years…
Living with Acute Leukemia
Rhonda
This is my second time participating in the Light The Night as a cancer survivor. I have had blood cancer twice. In 2012 I was diagnosed with Non-H…
Ashley
Three little words changed my life forever!My name is Ashley, and I am a leukemia survivor. When I was 20 years old, I was diagnosed with chronic myel…
Krista
Where do I begin? I am a 2x acute myeloid leukemia (AML) survivor diagnosed for the first time in 2008 at the age of 38. My family and I received amaz…
Greg
In 2017, our world turned upside down when my father, Greg, was diagnosed with acute myeloid leukemia (AML). The only chance to save his life was a bo…
Donna
I would first and foremost like to introduce you to a most special lady. My Nana.She was my grandmother—my dad’s mom. Her name was Donna. She was dia…