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How Do I? Video series
In our series of short videos, cancer survivors and experts guide you through issues that you may face after a cancer diagnosis. Topics include:Insur…
Education Resources
CEBPA mutations in the pathogenesis of leukemia
mutations affecting the basic leucine zipper (bZIP) domain of C/EBPα characterize a distinct subset of acute myeloid leukemia with relatively favorabl…
Leveraging the ubiquitin proteasome system for targeted therapy in Acute Myeloid Leukemia
This research proposal will investigate the role of protein degradation in acute myeloid leukemia (AML). Specifically, we will assess the function of…
The Adventures of Peighten and Gingerbread
Based on the relationship between the author & licensed therapist’s daughter, Peighten, & her late grandmother, who passed away after her battle with …
A Phase I/II Study of the Combination of ALX148, Rituximab and Lenalidomide in Patients with Indolent and Aggressive B-cell Non-Hodgkin Lymphoma
SIRPα+ macrophages mediate resistance to lenalidomide in lymphoma, limiting the activity of immunotherapy for these patients. Therefore, we propose a…
Niclosamide for the Treatment of Relapsed/Refractory Pediatric Acute Myeloid Leukemia
Niclosamide is an FDA approved drug that is well tolerated and acts synergistically with chemotherapy to kill AML cells. We will conduct a Phase I cl…
Clinical and molecular determinants of CLL eradication with targeted combination therapy
The genomic architecture of residual CLL and molecular determinants of disease progression after targeted combination therapy are unknown. In a phase …
Characterization and Targeting of Tumor-Associated Monocytes/ Macrophages that Limit the Efficacy of PD-1 Blockade in Lymphoma
Inhibition of the exhaustion pathway enables the immune system to attack cancers. blockade is now a standard treatment for relapsed classic Hodgkin …
CD70-directed CAR T-cell therapy for the treatment of relapsed/refractory pediatric AML
In this project, we will test an innovative therapy called CAR therapy for children with a type of cancer called AML. In the laboratory, we have iden…
Suggested Reading - Beyond the Diagnosis: Surviving and Thriving with Multiple Myeloma and Breast Cancer
"Beyond the Diagnosis: Surviving and Thriving with Multiple Myeloma and Breast Cancer" unfolds an inspiring narrative that transcends the boundaries o…
Suggested Reading - Brain Tumors - Leaving the Garden of Eden
This is a survival guide to diagnosis, learning the basics, getting organized and finding your medical team, was written specifically for patients and…
Precision Medicine Inhibitor and Immunotherapy Approaches for High-Risk Childhood Leukemias
Dr Tasian’s scientific passion is successful development of precision medicine therapies for childhood leukemia. Her translational laboratory researc…
T-cell immunotherapy for prevention of COVID-19 following bone marrow transplantation
infections may be prolonged in cancer patients and may enable intrahost development of virulent viral variants. Adoptive immunotherapy with has been…
Shining Stars Foundation
To transform lives through outdoor recreational and social programs for children and their families challenged with pediatric cancer or other illness…
Lia
My dad, Arthur, and I were super close my entire life. He was always my person. He was diagnosed with chronic myeloid leukemia (CML) that converted to…
Stories
American Society for Reproductive Medicine (ASRM)
ASRM is a multidisciplinary organization dedicated to the advancement of the art, science and practice of reproductive medicine. The Society accomplis…
Targeting the MMP-13/PD-1H signaling axis for multiple myeloma bone disease and immunosuppression
Multiple myeloma is an incurable blood cancer complicated by bone diseases and compromised immune system. Our work indicated that checkpoint inhibitor…
Booklet Updates
Blood Cancer United wants you to have the most information about blood cancer treatment. See below for new treatments that have been FDA approved sin…
Chris
Chris is a retired Army colonel. He graduated from Temple University and set into life at home with his family when he was diagnosed with a hernia. In…
Targeting the cell surface U5 snRNP complex as a novel immunotherapy for AML
A major limitation of immunotherapy approaches for AML has been the lack of known targetable cell surface antigens specific to AML cells. This project…
Mantle Cell Lymphoma Video Vignettes for Healthcare Professionals
Developed through a collaboration between The Leukemia & Lymphoma Society & The Association of Cancer Care Centers.This video series provides an overv…
Education Resources
Improving Immunotherapy in Multiple Myeloma Through Innovative Clinical Trials, Real-World Evidence and Correlative Research
The overall focus of my research is improving outcomes with immunotherapy in multiple myeloma. I will accomplish this through ) novel clinical trials…
Impaired dynamic nucleosome remodeling as a leukemogenic mechanism and therapeutic target in AML
The cohesin and BAF complexes are both epigenetic regulators of dynamic chromatin accessibility. Recurrent mutations are observed in proteins of both …
Acute lymphoblastic leukemia (ALL) diagnosis
Diagnosing acute lymphoblastic leukemia (ALL) and your ALL subtype usually involves a series of tests. An accurate diagnosis of your subtype is import…
Blood Cancer
Impact of sublethal radiation dose on tumor response, microenvironment and the immune system
Extremely low dose radiation can improve blood cancer outcomes. But the mechanisms of how sublethal radiation (SRT) affects tumors, the microenvironme…