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Optimized, computationally engineered CD70-targeting CAR-T cells for high-risk multiple myeloma
Despite an array of promising immunotherapies, the blood cancer multiple myeloma still remains without any known cure. Patients with disease in parti…
β-Hydroxybutyrate To Enhance CAR T Cell Immunotherapy Against Hematological Cancers
This project aims to enhance CAR therapy, a promising treatment for blood cancers, by leveraging the ketogenic diet and its key byproduct, (BHB). We…
Gene-edited CD19 CAR-T cells with superior proliferation, persistence and serial-killing activity
A therapy for blood cancers reprograms a patient’s T cells to kill tumor cells. This treatment, called cell therapy, can work well, but the often r…
Joseph Tuscano
In , I began as an academic physician at UC Davis. I developed a productive, independent research program, and as the Director of Hematologic Maligna…
Michael Girardi
The in his family to attend college, Dr. Girardi is the Evans Professor of Dermatology and Vice Chair of Faculty Development & Scientific Innovation …
Personalized Anti-TCRVbeta2 therapeutic antibody and ADC for T Cell Leukemias and Lymphomas
T cell cancers together comprise ~% of acute leukemias and 's lymphomas. A major challenge with currently available treatments for these is that the t…
Shih-Shih Chen
My lab focuses on the tumor microenvironment as a risk factor for chronic lymphocytic leukemia (CLL) and Richter's transformation (RT). We develop the…
Targeting TLR9 Signaling to restore immunomodulating function of FRCs in Richter's Transformation
Richter’s transformation (RT) refers to the development of an aggressive lymphoma in patients with a prior diagnosis of chronic lymphocytic leukemia (…
Understanding and targeting rare Ag–(CD19/CD20–) Follicular Lymphoma cells to prevent post-immunotherapy antigen escape
Follicular lymphoma (FL) affects ~, Americans and is, unfortunately, frequently referred to as incurable, however, that may change in the near future.…
Joshua Brody
Dr. Brody is Director of the Lymphoma Immunotherapy Program at Mount Sinai and a member of the Depart of Immunology.
Investigating the tumor-unique mannose-lectin interaction for a novel diagnostic, prognostic and therapeutic antibody approach of follicular lymphoma
We have discovered that the tumor cells of the vast majority of follicular lymphoma cases have a unique feature in their major receptor. This is an e…
Francesco Forconi
Professor Forconi is a clinician scientist and leader of the Cancer Group, comprising lymphoma scientists and clinicians in the University of Southam…
Blood Cancer United Statement on New NCI Head, Dr. Anthony Letai
Washington, D.C., September , —Blood Cancer United®, formerly The Leukemia & Lymphoma Society, applauds the choice of Dr. Anthony Letai to lead the Na…
News Release
Michael Green
Dr. Michael Green is an Associate Professor and Vice Chair for Research in the Department of Lymphoma & Myeloma at the University of Texas MD Anderson…
Lipid-dependent regulation of oncogenic signaling in DLBCL growth and therapeutic response
Certain genetic alterations in Diffuse Large B Cell Lymphomas (DLBCL) render these tumors highly aggressive. Aggressive DLBCLs may also form secondary…
Inherited resilience to clonal hematopoiesis and myeloid malignancy by modifying stem cell RNA regulation
This grant proposal aims to uncover inherited resilience to clonal hematopoiesis (CH) and myeloid malignancies (MyMs). Our pilot work has identified a…
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Vijay Sankaran
Vijay G. Sankaran, MD, PhD is the Jan Ellen Paradise, MD Professor of Pediatrics at Harvard Medical School, an Investigator of the Howard Hughes Medic…
Angelia
My name is Angelia, and I’m a mother, entrepreneur, and the founder of Hope Magazine. In July , after nearly two years of unexplained symptoms and una…
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Patrick
In , I was diagnosed with skin cancer, mycosis fungoides with large cell transformation, a form of cutaneous lymphoma (CTCL). They treated it with a …
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Brian
My cancer journey started in January . I was so excited that I got through thinking I hadn't gotten sick at all. In my mind, the pandemic was over, a…
Abby
I was diagnosed with acute myeloid leukemia (AML) at the age of in April . I am a mom to a now who I had to be apart from for four months to get tre…
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Cassandra
On April , , I lost my loving husband, Dylan, to stage diffuse large lymphoma (DLBCL). He was only years old — far too young — leaving behind a bea…
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Emily
I am a woman. I am a daughter. I am a sister. I am a friend. I am a professional runner for Nike. And I am a childhood cancer survivor.Most people who…
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Adam
I found out in February that I had stage Hodgkin lymphoma (HL) at the age of . I could barely walk as my feet were swollen from the lymphedema. My b…
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