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Autologous stem cell transplantation
In autologous stem cell transplantation, the procedure uses the patient’s own stem cells for the transplant. The stem cells are collected from the pat…
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Autologous stem cell transplantation for children and teens
In autologous stem cell transplantation, the procedure uses the patient’s own stem cells for the transplant. The stem cells are collected from the pat…
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Autologous stem cell transplantation for young adults
In autologous stem cell transplantation, the procedure uses the patient’s own stem cells for the transplant. The stem cells are collected from the pat…
Support Resources
Relevance of ubiquitin dependent proteolysis in diffuse large B-cell lymphoma
The goal of this proposal is to investigate the significance of genes of the ubiquitin proteasome system (UPS) that are mutated in Diffuse Large Lymp…
Impact of Health Insurance on Mortality for Children and AYAs Newly Diagnosed with a Blood Cancer: A Population-Based Multistate Evaluation
Lacking continuous insurance is a key barrier to access to timely care. This study will provide the first evidence of whether insurance continuity pro…
Inflammation-responsive mechanisms of malignant stem cell generation and eradication in multiple myeloma
The focus of my research is to elucidate the core molecular regulators of malignant stem cell generation in multiple myeloma. My approach addresses th…
Metabolic Regulation of Leukemic Cell Fate
metabolic processes are dysregulated in acute myeloid leukemia (AML) and can act to sustain an oncogenic state of differentiation arrest. Using AML ce…
Identifying novel regulators of leukemic progression in GATA2-deficiency syndrome
GATA2 deficiency is an inherited pediatric syndrome with a high rate of progression to myeloid malignancy, the mechanisms of which remain largely unde…
Modeling LSC heterogeneity at unprecedented resolution in AML
Our goal is to perform molecular characterization of human leukemia stem cells (LSCs). We have developed an integrated set of techniques that will a…
Targeting Microenvironment Determinants in Peripheral T-cell Lymphoma
Peripheral lymphomas are highly aggressive blood cancer that have very poor survival rate, highlighting the need for new therapies to improve patient…
Suggested Reading - Henry and the White Wolf
Written and illustrated by a teenage brother and sister, this is an allegory about a sick hedgehog that is healed by the feared white wolf. Geared to …
LCK-targeted Therapy in T cell Acute Lymphoblastic Leukemia
acute lymphoblastic leukemia () is a highly aggressive leukemia in adults with -year survival rate of only about % in patients with relapsed/refractor…
The Andrew McDonough B+ Foundation
The Andrew McDonough B+ Foundation has four areas of focus: financial assistance, childhood cancer research, awareness and spreading positivity …
Understanding the role of Metabolic Regulator SIRT5 in Acute Lymphoblastic Leukemia
p>SIRT5 is a master regulator of central energy metabolism. The survival and growth of Acute Myeloid Leukemia (AML) cells depend on SIRT5. I will e…
Research: Grants
Taylor
Meet Taylor Carol. survivor to singer. Taylor started singing in the 4th grade, until he was diagnosed with acute lymphoblastic leukemia at just year…
TCR T cells for the treatment of SRSF2 mutant myeloid neoplasms
Mutations in the RNA splicing factor gene SRSF2 occur in % of patients with MDS, % of patients with chronic myelomonocytic leukemia (CMML), and % of A…
Establishing longitudinal outcomes and clinical prognosticators in pediatric and young adult B-ALL after commercially available CD19-CAR T cells
While many immunotherapy studies in children with leukemia focus on establishing early responses, this project studies what life is like, and what hea…
Targeted combination therapies for leukemia with NUP98 translocations
Leukemia patients with chromosomal translocations of the Nucleoporin (NUP98) gene suffer from very poor prognosis. In this project we will identify ne…
Understanding and Overcoming Mechanisms of Immune Evasion after Allogeneic Transplant
Outcomes for patients with acute myelogenous leukemia who relapse after transplantation are dismal. This SCOR brings together an international group o…
Genomic and epigenomic interactions of complex structural variants affecting outcome in multiple myeloma
Multiple myeloma is characterized by severe changes in chromosomes that result in gains or losses of genetic material. Several key events disrupt the …
Suggested Reading - Handbook for Mortals: Guidance for People Facing Serious Illness
Designed for caregivers as well as patients, this book combines insight and inspiration with practical information and suggestions for coping with cri…
A precision-based all-oral combination of venetoclax, oral decitabine, and IDH1/2 targeted inhibition for patients with IDH1 or IDH2 mutated AML
My ultimate goal is to develop more effective, better tolerated, and individualized treatment for patients with AML. This project focuses on AML patie…
Get Palliative Care
To increase the availability of quality palliative care services for all people living with serious illness. Provides information about palliat…
Oncology Nursing Society (ONS)
To promote excellence in oncology nursing and quality cancer care. ONS is a professional organization of over , registered nurses and other heal…
Javier
Javier was diagnosed with pre b ALL leukemia in October . He was in and out of the hospital for over a year and he has been through a lot.Javier is so…