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Headshot of award recipient Jennifer Trowbridge

Jennifer Trowbridge

The Jackson Laboratory

Bar Harbor, ME
United States

Discovery of Aging-Driven Mechanisms Causing Clonal Hematopoiesis (CH) and its Progression to Hematological Malignancy

My research focuses on why and how risk of acute myeloid leukemia (AML) increases with aging. Studying naturally aged mouse models in combination with mice engineered to express mutations commonly found in human blood stem cells with aging, we are investigating whether certain inflammatory factors that increase during aging increase the risk of leukemia. My goal is to identify biomarkers to assess risk of AML development in aging individuals and define new therapeutic targets to prevent AML.

Program: Career Development Program

Project Term: January 1, 2021 - December 31, 2025

woyach-jennifer_web_sq_dam_file_162356.jpg

Jennifer Woyach

The Ohio State University

Columbus, OH
United States

Overcoming BTK Inhibitor Resistance in Chronic Lymphocytic Leukemia

Coming soon.

Program: Career Development Program

Project Term: April 1, 2021 - March 21, 2026

Photo of Grant Recipient Jae Park

Jae Park

Sloan Kettering Institute for Cancer Research

New York, NY
United States

Developing novel therapeutic approaches for classical and variant hairy cell leukemia

In this proposal, we have combined clinical and research expertise in HCL across Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, the University of Pennsylvania, and Yale University to develop newer targeted therapeutics for every stage and subtype of hairy cell leukemia. Capitalizing on this combined expertise, our proposal stands to significantly advance treatment strategies for hairy cell leukemia through the following aims: to test BRAF inhibition for initial treatment of classical hairy cell leukemia, test new oral inhibitors of the MAP kinase signaling pathway known as ERK inhibitors in both classical and variant hairy cell leukemia, evaluate totally new treatments that degrade BRAF, and develop T-cell immunotherapies for the first time in hairy cell leukemia.

Program: Hairy Cell Leukemia Research Initiative

Project Term: October 1, 2021 - September 30, 2026