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Chronic lymphocytic leukemia (CLL) signs and symptoms

Healthy people often have a sign or a symptom when they get an illness or a disease. A sign is a change in the body that the doctor sees in an exam or a test result. A symptom is a change in the body that the patient can see or feel. 

Many signs and symptoms of CLL are the same signs and symptoms that are caused by other illnesses. Most people with signs and symptoms of CLL do not have CLL, but may have another disease or condition.  

Some people with CLL have no symptoms. They may find out they have CLL after a routine blood test. A high number of lymphocytes in the blood is often the first sign of CLL. 

Signs and symptoms of CLL

Generally, CLL symptoms develop slowly over time. For patients who have symptoms, they may include: 

  • Infections
  • Extreme tiredness, lack of energy
  • Shortness of breath during normal physical activity
  • Lymph node enlargement (particularly in the neck)
  • Low-grade fevers
  • Unexplained weight loss
  • Night sweats
  • Feelings of fullness below the ribs (due to an enlarged spleen or liver) 

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