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Biology and therapeutic targeting of cohesin mutations during myeloid malignancy development
We investigate the biology, genetics and treatment of myeloid malignancies, including CHIP, MDS and AML. Our goal is to improve our understanding of t…
Impact of genetic ancestry on tumor biology and survival outcomes in T-ALL and T-LL
Outcomes for children with and have improved, yet prognosis for children with relapsed disease is dismal. A critical gap remains in identifying pat…
Defining the role of IL-17A in propelling clonal cytopenia of undetermined significance
Clonal cytopenia of undetermined significance (CCUS) is a poorly understood precursor condition linking clonal hematopoiesis with myeloid malignancy. …
The Role of TP53 in Mutant U2AF1 Myelodysplastic Syndromes
This project aims to understand why splicing factor gene mutations paradoxically impair the growth of hematopoietic progenitors. We will use mouse com…
Improving CAR-T cell therapy outcomes for patients with for aggressive lymphoma and multiple myeloma
Despite the promise of cell immunotherapy for patients with lymphoma and multiple myeloma, a significant proportion of patients fail to respond or re…
Overcoming RAS-driven Mechanisms of Resistance in Leukemia
The protein kinase (MAPK) pathway is activated in leukemia and is a hallmark of resistance to therapies. This project uses xenograft models of rela…
CHEK2 as a predisposition gene for clonal hematopoiesis and hematopoietic malignancies
This proposal explores how inherited mutations in the DNA repair gene CHEK2 lead to blood cancers. Our work employs two unique resources: cell lines …
Healing Happens Around The Dinner Table
Too many parents lose their children to blood cancer each year. It’s a devastating experience for families blindsided by the harsh realities of cancer…
“People Just Didn’t Get It”: Treating Young Adults with Cancer
Think of spring break: warm sunny skies, a refreshing drink, and hopefully, a feeling of freedom. Allison Rosenthal was dreaming of all of it in her …
Dr. Bhatia
Smita Bhatia, M.D., M.P.H., is focused on cancer survivorship and quality of life. She studies the mechanisms underlying long term and late effects re…
Dawnya
This is me and my bald head on vacation in California. I was diagnosed with leukemia when I was /.My parents made sure that my life was as normal as …
Debra
I was diagnosed with lymphoma in , just several months after my husband was required to go on dialysis for polycystic kidneys. We had three very youn…
Tate
On my 12th birthday, I was diagnosed with Burkitt Lymphoma (BL), a highly aggressive form of lymphoma (terrible birthday present, btw!). At the time…
Dare 2 Dream
Stories
William
years ago (May ), I was diagnosed with chronic lymphoblastic leukemia (CLL). As anyone who has had a diagnosis of cancer understands, depression set i…
Thomas/TJ
This picture is of my brother and my son. Both fought valiantly from acute lymphoblastic leukemia (ALL) and Hodgkin's lymphoma respectively. It sta…
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Emily
My daughter, Emily is my hero! She is years old and was diagnosed with Hodgkin lymphoma in June . Her initial symptoms started with a cough and her l…
Harnessing METTL3 inhibition in acute megakaryoblastic leukemia driven by the t(1;22) fusion involving a member of the m6A writer complex
I want to understand how the t(;) translocation that involves a member of the m6A writer complex drives acute megakaryoblastic leukemia (AMKL). To ide…
Cancer Financial Assistance Coalition (CFAC)
A coalition of financial assistance organizations joining forces to help cancer patients experience better health and by limiting financial challenge…
Job Accommodation Network (JAN)
To develop and influence disability policies and practices; is a service of the U.S. Department of Labor’s Office of Disability Employment Policy. …
The PRMT5-p53-DUSP6 Axis: Integral Regulators of Cytokine Signaling in Hematopoietic Cells and AML Oncogenesis
This research investigates how the PRMT5-p53-DUSP6 axis regulates cytokine signaling in hematopoietic stem cells and its implications for AML (acute m…
Special Days Camps
To provide a safe and memorable camping opportunity in a environment for children who have experienced cancer and their siblings, servicing the entir…
Living the Good Fight: A Mother's Journey of Faith Hope and AML
In "Living the Good Fight" author Tracey Kearcher shares her journey with Acute Myeloid Leukemia and how her faith and family helped her to discover t…
Russ
Shockingly I was diagnosed with acute myeloid leukemia (AML) on February , ! My wife Nancy and I were devastated and had zero background or experience…
Heart, kidneys, liver and lung function in young adults
Some cancer treatments can affect the function of major organs like the heart, kidneys, liver and lungs. Your doctor will monitor you closely for any …
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Heart, kidneys, liver and lung function in children and teens
Some cancer treatments can affect the function of major organs like the heart, kidneys, liver, and lungs. Your child's doctor will monitor them closel…