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Identification of novel therapeutic strategies for aggressive subtypes of CTCL

In this proposal, the Choi lab is investigating mechanisms that underlie aggressive forms of T cell lymphoma. They have found a gene mutation that is …

A precision-based all-oral combination of venetoclax, oral decitabine, and IDH1/2 targeted inhibition for patients with IDH1 or IDH2 mutated AML

My ultimate goal is to develop more effective, better tolerated, and individualized treatment for patients with AML. This project focuses on AML patie…

Exploiting metabolic dependencies, tumor plasticity and their consequences for drug response of HCL

We have long standing experience in the field of HCL research. The aim of this research proposal is to characterize HCL on single cell level across mu…

Reaching out to underserved & minority patients with hematological diseases in the southeastern US

Cancer Center (VICC) is the only NCI designated cancer center that serves both adult and pediatric populations in TN, one of the highest states in th…

CAR T-cell therapy in central nervous system (CNS) lymphoma: a study in safety and efficacy and a model in which to study mechanisms of neurotoxicity

CAR are highly effective in lymphoma but limited by a profound and potentially fatal toxicity involving the central nervous system (CNS). Little is k…

T-cell immunotherapy for prevention of COVID-19 following bone marrow transplantation

infections may be prolonged in cancer patients and may enable intrahost development of virulent viral variants. Adoptive immunotherapy with has been…

REACH: Recruitment Expansion through community Access to Clinical trials in Hematologic malignancies

Mayo Clinic Rochester (MCR) is a tertiary center with , blood cancer visits annually. Circa % of patients referred to MCR come from states: MN, WI, I…

Multi-modal Immunotherapeutic Targeting of AML-restricted Targets in Infants and Children

Advances in understanding and management of AML in children has been stagnant for decades. Observed improvements in survival are more directly linked …

Neonatal origins of pediatric AML

Children get different types of leukemias than adults. Even if the leukemias look the same under the microscope, the mutations are different. We are t…

Cellular Crosstalk In The Normal And Malignant Bone Marrow

We want to understand how leukemia inhibits blood production as this is one of the main causes of death in leukemia patients. We use new microscopy te…

Lincoln, smiling standing by his hospital bed during treatment

Lincoln

In the fall of , Lincoln was not feeling well and had typical cold virus symptoms. He also had a recurring fever and an unexplained rash. After two tr…

BRIDGE (Blood cancer Research Initiative Developing Greater Engagement) with community patients

The Weill Cornell Medicine (WCM) Meyer Cancer Center (MCC) has an internationally recognized, clinical/translational blood cancer research program foc…

A phase 1 study of CB-010, a CRISPR-edited allogeneic CAR-T targeting CD19, in patients with B-cell NHL

In February , LLS made an equity investment in Caribou Biosciences to support "A Phase , Multicenter, Study of , a Allogeneic Cell Therapy in Pati…

Medicine Assistance Tool

To help patients, caregivers, and healthcare providers learn more about the resources available through various biopharmaceutical industry programs. …

BMT InfoNet’s Mental Health Directory

BMT InfoNet’s Mental Health Directory provides a searchable directory of psychologists, social workers and other counselors who have experience workin…

Living with Multiple Myeloma

Topics Covered We invite you to learn more about: New and emerging therapies for myeloma What to do when myeloma relapses CAR therapy for myelo…

Avery looking at her ipad, a cancer survivor

Avery

I am writing as a parent of a cancer survivor. My daughter, Avery Smith, who is now years old, was diagnosed at ½ years old with leukemia. In , our t…

Translational Discovery in Peripheral T-Cell Lymphomas

Peripheral lymphomas (PTCLs) are poorly understood and patients with PTCL are underserved by current therapies. The most common subtypes (among >)…

AML Strategies: Decision-Making at Each Point in Care

This series of four modules will provide members of the multidisciplinary cancer care team with the latest information to improve their knowledge and …

A phase 1 study of CB-011, a CRISPR-edited allogeneic CAR-T targeting BCMA, in patients with multiple myeloma

In February , LLS made an equity investment in Caribou Biosciences to support "A Phase , Multicenter, Study of , a Allogeneic Cell Therapy in Pati…

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