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Forest
In September , our world crashed when I was diagnosed with acute lymphoblastic leukemia (ALL). Over the next several years, I experienced numerous che…
Understanding the role of Metabolic Regulator SIRT5 in Acute Lymphoblastic Leukemia
p>SIRT5 is a master regulator of central energy metabolism. The survival and growth of Acute Myeloid Leukemia (AML) cells depend on SIRT5. I will e…
Research: Grants
Taylor
Meet Taylor Carol. survivor to singer. Taylor started singing in the 4th grade, until he was diagnosed with acute lymphoblastic leukemia at just year…
TCR T cells for the treatment of SRSF2 mutant myeloid neoplasms
Mutations in the RNA splicing factor gene SRSF2 occur in % of patients with MDS, % of patients with chronic myelomonocytic leukemia (CMML), and % of A…
Establishing longitudinal outcomes and clinical prognosticators in pediatric and young adult B-ALL after commercially available CD19-CAR T cells
While many immunotherapy studies in children with leukemia focus on establishing early responses, this project studies what life is like, and what hea…
Oncology Nursing Society (ONS)
To promote excellence in oncology nursing and quality cancer care. ONS is a professional organization of over , registered nurses and other heal…
Javier
Javier was diagnosed with pre b ALL leukemia in October . He was in and out of the hospital for over a year and he has been through a lot.Javier is so…
Targeted combination therapies for leukemia with NUP98 translocations
Leukemia patients with chromosomal translocations of the Nucleoporin (NUP98) gene suffer from very poor prognosis. In this project we will identify ne…
Understanding and Overcoming Mechanisms of Immune Evasion after Allogeneic Transplant
Outcomes for patients with acute myelogenous leukemia who relapse after transplantation are dismal. This SCOR brings together an international group o…
Genomic and epigenomic interactions of complex structural variants affecting outcome in multiple myeloma
Multiple myeloma is characterized by severe changes in chromosomes that result in gains or losses of genetic material. Several key events disrupt the …
Suggested Reading - Handbook for Mortals: Guidance for People Facing Serious Illness
Designed for caregivers as well as patients, this book combines insight and inspiration with practical information and suggestions for coping with cri…
A precision-based all-oral combination of venetoclax, oral decitabine, and IDH1/2 targeted inhibition for patients with IDH1 or IDH2 mutated AML
My ultimate goal is to develop more effective, better tolerated, and individualized treatment for patients with AML. This project focuses on AML patie…
Get Palliative Care
To increase the availability of quality palliative care services for all people living with serious illness. Provides information about palliat…
Targeting the inflammasome in CMML
Overactivation of the inflammasome is seen in CMML and leads to worsening of this condition. We will explore the potential of a new inflammasome inhib…
CAR T-Cell Therapy: A Path of Hope and Healing
This docuseries was created to to inform blood cancer patients, caregivers, healthcare providers, and the public about the revolutionary progress of c…
Cancer Legal Resource Center (CLRC)
To provide information and resources on legal issues to cancer patients, survivors, caregivers, health professionals, employers, and others coping wi…
Dr. Green
Anthony Green, M.D., Ph.D., leads an LLS Specialized Center of Research grant.His work is aimed at understanding at the genomic scale how patients wit…
Steven
I have a rare blood cancer. It is Waldenstrom macroglobulinemia (WM), a type of lymphoma (NHL), but some doctors say it has the same characteristics …
Stories
Stratified treatment of newly diagnosed MCL based on the presence or absence of high risk features utilizing non-cytotoxic agents.
We believe that regimens without chemotherapy can induce significant and durable remissions in patients with Mantle cell lymphoma (MCL). We will confi…
Improving CAR T-cell Therapy Efficacy in Acute Lymphoblastic Leukemia by Optimizing Design and Placement
Pediatric acute lymphoblastic leukemia (ALL) that is resistant to standard therapy is a challenge that has been partially overcome by therapy, yet re…
Targeting GCK as a novel and selective therapeutic strategy against RAS mutated Multiple Myeloma
RAS/MAPK mutations are the key drivers in MM, which occurs in % of newly diagnosed and higher in relapsed MM patients. However, RAS remains undruggabl…
Mona
I was years old when I was diagnosed with stage Hodgkin lymphoma (HL). That was in , and I can now proudly say I’ve been for years! But being a -y…
Limited-duration bispecific antibody therapy for multiple myeloma
Bispecific antibodies are a new, highly effective immunotherapy for multiple myeloma. Most bispecific antibody therapies have been tested as continuou…
Suggested Reading-My Dad and the Dragon
My Dad and the Dragon is a children's picture book that honestly describes what it is like when your father is diagnosed with cancer through the alleg…
American Association of Sexuality Educators, Counselors and Therapists (AASECT)
AASECT is a , interdisciplinary professional organization of individuals who share an interest in promoting understanding of human sexuality and healt…