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DNA damage, immune response, aging and leukemia
Hematopoiesis is tightly regulated by intrinsic and extrinsic signals, alterations of which can affect hematopoietic stem cell (HSC) function and lead…
Biology and therapeutic targeting of cohesin mutations during myeloid malignancy development
We investigate the biology, genetics and treatment of myeloid malignancies, including CHIP, MDS and AML. Our goal is to improve our understanding of t…
Defining the role of IL-17A in propelling clonal cytopenia of undetermined significance
Clonal cytopenia of undetermined significance (CCUS) is a poorly understood precursor condition linking clonal hematopoiesis with myeloid malignancy. …
The Role of TP53 in Mutant U2AF1 Myelodysplastic Syndromes
This project aims to understand why splicing factor gene mutations paradoxically impair the growth of hematopoietic progenitors. We will use mouse com…
CLL Patient Databases
Maintains information on a large number of patients with chronic lymphocytic leukemia to contribute to medical research about its diagnosis, prognosis…
National Cord Blood Program of the New York Blood Center
To investigate cord blood as a possible solution to a critical public health need: finding appropriate hematopoietic transplants for patients who have…
U.S. Equal Employment Opportunity Commission (EEOC)
EEOC is responsible for enforcing federal laws that make it illegal to discriminate against a job applicant or an employee because of the person's rac…
PROFILE: Investigating Breast Implant Associated ALCL
To better understand the role of breast implants in the etiology of primary Anaplastic Large Cell Lymphoma (ALCL). PROFILE: Patient Registry …
Have a Nice Day Foundation
To bring sunshine to parents with cancer, by granting extraordinary experiences (Nice*Days) and creating lasting memories for families fighting cancer…
Jamaal
Jamaal had lymphoma (NHL). He was such a brave person. He worked at Publix supermarket and he went to Clark Atlanta University. He was about to gradu…
Improving CAR-T cell therapy outcomes for patients with for aggressive lymphoma and multiple myeloma
Despite the promise of cell immunotherapy for patients with lymphoma and multiple myeloma, a significant proportion of patients fail to respond or re…
Overcoming RAS-driven Mechanisms of Resistance in Leukemia
The protein kinase (MAPK) pathway is activated in leukemia and is a hallmark of resistance to therapies. This project uses xenograft models of rela…
CHEK2 as a predisposition gene for clonal hematopoiesis and hematopoietic malignancies
This proposal explores how inherited mutations in the DNA repair gene CHEK2 lead to blood cancers. Our work employs two unique resources: cell lines …
Hope Air
To arrange free flights for Canadians who are in financial need and must travel to healthcare.
William
years ago (May ), I was diagnosed with chronic lymphoblastic leukemia (CLL). As anyone who has had a diagnosis of cancer understands, depression set i…
Thomas/TJ
This picture is of my brother and my son. Both fought valiantly from acute lymphoblastic leukemia (ALL) and Hodgkin's lymphoma respectively. It sta…
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Emily
My daughter, Emily is my hero! She is years old and was diagnosed with Hodgkin lymphoma in June . Her initial symptoms started with a cough and her l…
Russ
Shockingly I was diagnosed with acute myeloid leukemia (AML) on February , ! My wife Nancy and I were devastated and had zero background or experience…
Heart, kidneys, liver and lung function in young adults
Some cancer treatments can affect the function of major organs like the heart, kidneys, liver and lungs. Your doctor will monitor you closely for any …
Support Resources
Heart, kidneys, liver and lung function in children and teens
Some cancer treatments can affect the function of major organs like the heart, kidneys, liver, and lungs. Your child's doctor will monitor them closel…
Brescia
I am a Hodgkin lymphoma (HL) cancer survivor. I was diagnosed with cancer during my college years and took a semester off to begin chemotherapy and tr…
Dare 2 Dream
Helena
In , a few days before Thanksgiving, Helena noticed something. She was having difficulty lifting speakers at her gigs. She became winded after only a …
Geoffrey
My wife was diagnosed with acute lymphoblastic leukemia (ALL) in November . She went through a protocol of a steroid regimen followed by one year of …
Tasnim
What started as an internship opportunity turned into so much more for Tasnim when she began working with LLS in the summer of . Tasnim, who is pursu…
Harnessing METTL3 inhibition in acute megakaryoblastic leukemia driven by the t(1;22) fusion involving a member of the m6A writer complex
I want to understand how the t(;) translocation that involves a member of the m6A writer complex drives acute megakaryoblastic leukemia (AMKL). To ide…