Search Results

CEBPA mutations in the pathogenesis of leukemia

mutations affecting the basic leucine zipper (bZIP) domain of C/EBPα characterize a distinct subset of acute myeloid leukemia with relatively favorabl…

Xiaodi Wu

Xiaodi Wu, MD, PhD, is an Instructor of Medicine at Memorial Sloan Kettering Cancer Center (MSKCC).

Nicotinamide metabolism is essential for myelodysplastic syndrome stem and progenitor cell function and survival

Myelodysplastic syndrome (MDS) is a fatal disease with limited therapeutic opportunities. To increase survival rate, it is essential to identify thera…

Sweta Patel

I am a scientist of Indian origin who moved to the US upon completion of a Master’s in Pharmaceutical Biotechnology degree. I obtained my PhD in Cance…

Christopher Hergott

Christopher Hergott, M.D., Ph.D. is a postdoctoral fellow at the Cancer Institute (DFCI) and Associate Pathologist in hematopathology at Brigham and …

Defining the role of IL-17A in propelling clonal cytopenia of undetermined significance

Clonal cytopenia of undetermined significance (CCUS) is a poorly understood precursor condition linking clonal hematopoiesis with myeloid malignancy. …

Characterizing the epigenetic mechanisms of inflammation-mediated fitness advantage in clonal hematopoiesis

Clonal hematopoiesis (CH) often precedes AML development, yet the molecular basis of CH expansion and progression to AML remains a mystery. By deployi…

Alba Rodriguez-Meira

I was an endlessly curious child who wanted to become a scientist. But it was my own experience as a teenager in a Pediatric Hospital Unit that shaped…

Abhilash Barpanda

I am a postdoctoral researcher at UCSF, aiming to advance proteomic technologies for target discovery and redefine immunotherapy in blood cancers. In …

“Open-Surfaceomics” for Identifying Novel Surface PTMs as Immunotherapy Targets in AML

A lack of highly selective surface antigens for Acute Myeloid Leukemia (AML) immunotherapy is a major bottleneck in the development of both CAR T cell…

Identifying Mechanisms of Chemoresistance Induced by MECOM in Primary-Refractory Acute Myeloid Leukemia

Approximately % of Acute Myeloid Leukemia (AML) patients are “” () and fail to go into remission with intensive induction chemotherapy. These patients…

Michael Bern

Dr. Bern is a fellow in Dr. Timothy Ley’s lab at Washington University School of Medicine and a clinical fellow in the Hematology and Oncology progra…

Synthetic introns to target U2AF1 mutant leukemias and dissect molecular basis for mis-splicing

Mutations affecting RNA splicing factors are the most common class of mutations in patients with myelodysplastic syndromes and related myeloid neoplas…

Qian Zhang

Qian Zhang is a postdoctoral fellow in the Dr. ’s lab at Memorial Sloan Kettering Cancer Center. She developed synthetic introns to selectively target…

Unraveling the Cellular and Molecular Origins of B-cell Acute Lymphoblastic Leukemia in Down syndrome

Children with Down Syndrome (DS) have a -fold increased risk of Acute Lymphoblastic Leukemia (). We aim to identify the cells of origin in and defin…

Yue Wang

Yue Wang, PhD, is a postdoctoral researcher at UCLA with extensive expertise in developmental and stem cell biology. He earned his PhD in Regenerative…

Histone methyltransferases as key dependencies in SETBP1-mutant leukemias

This study aims to explore how mutant SETBP1 affects histone methyltransferase complexes to drive gene transcription. I will use biochemical, imaging…

Samantha Tauchmann

Samantha Tauchmann Ph.D. is a postdoc at the Oregon Health & Science University. She received a B.S. in Molecular Life Sciences from Maastricht Univer…

How does loss of chromosome Y perturb blood cell biology and create therapeutic vulnerabilities in acute myeloid leukemia?

Loss of chromosome Y (LOY) is common in acute myeloid leukemia (AML) yet the mechanistic and therapeutic roles of LOY remain largely unexplored. Using…