29 results

Refine Your Search

Ronald Levy
Board of Trustees of the Leland Stanford Junior University

This project is aimed at investigating a pre-clinical “off-the-shelf” CAR (chimeric antigen receptor) T-cell immunotherapy approach where the CAR cells are generated directly in the patient’s body. Importantly, this product will be a truly off the shelf therapy that is ready instantaneously and can be used repeatedly without the restriction of time-consuming manufacturing processes.

Project Term: July 1, 2020 - June 30, 2023

Margaret Shipp
Dana-Farber Cancer Institute

Dr. Shipp and her colleague, Scott J. Rodig, MD, Ph.D., are mapping the immune microenvironment in classical Hodgkin lymphoma.

Project Term: July 1, 2020 - June 30, 2023

Robert Signer
The Regents of the University of California, San Diego

Dr. Signer is investigating how the process of building defective proteins (inaccurate protein synthesis) plays a role in the development of a type of blood cancer called acute myeloid leukemia (AML) in the hopes of developing targeted therapies to treat this condition.

Project Term: July 1, 2020 - June 30, 2023

Daniel Starczynowski
Cincinnati Children's Hospital Medical Center

Dr. Starczynowski is investigating the role and potential benefit of therapeutic targeting of a protein called UBE2N in acute myeloid leukemia (AML).

Project Term: July 1, 2020 - June 30, 2023

Robert Bradley
Fred Hutchinson Cancer Research Center

The most common cause of MDS is a genetic mutation occurring in blood cells that affects a process called “RNA splicing”. The most commonly mutated RNA splicing factor gene is called SF3B1. We now know that many patients with MDS carry mutations in SF3B1 but we do not know why these mutations cause disease. Dr. Bradley proposes to determine how mutations in SF3B1 cause MDS and potentially create new opportunities for treating this disease.

Project Term: July 1, 2020 - June 30, 2023