Heart, kidneys, liver and lung function in children and teens

Some cancer treatments can affect the function of major organs like the heart, kidneys, liver, and lungs. Your child's doctor will monitor them closely for any adverse effects.

Heart

If cancer treatments are combined, such as chemotherapy with immunotherapies or other biological agents, they may be more likely to affect the heart. The effect may be temporary, but sometimes it can be permanent. Your child's doctor may test your heart function with an electrocardiogram (ECG) or another test(s) before each treatment session.

Kidneys

Many drugs are excreted through the kidneys. If your child has preexisting kidney damage or impaired kidney function, they may need modified doses of drugs. Their doctor will order blood tests to assess kidney function before starting therapy to determine whether a lower dose is needed.

Liver

If they have preexisting liver disease, they may need their doses reduced for drugs that are metabolized in the liver or excreted into the bile. Some anticancer agents may be toxic to the liver. Your child's doctor may test their blood periodically to assess their liver function and look for possible damage.

Lungs

Some chemotherapy or other cancer drugs can affect the lungs and breathing, with effects seen gradually over months or years. If your child is taking drugs that are likely to cause lung problems, their doctor will check their lung function during and after treatment. Let your doctor know if your child ever feels breathless. They can give you information about coping with shortness of breath.