Names
Besponsa® Inotuzumab OzogamicinIndications and usage
Inotuzumab ozogamicin is FDA approved for the treatment of relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) in adult and pediatric patients 1 year and older.
Side effects needing medical attention
Thrombocytopenia (low platelets), neutropenia (low neutrophils), infection, anemia, leukopenia (low white blood cells), fatigue, hemorrhage, pyrexia (fever), nausea, headache, febrile neutropenia, transaminases increased, abdominal pain, gamma-glutamyl transferase increased, and hyperbilirubinemia (increased bilirubin).
WARNING: Hepatotoxicity, including hepatic venoocclusive disease (VOD) (also known as sinusoidal obstruction syndrome) and increased risk of post-hematopoietic stem cell transplant non-relapse mortality. See full prescribing information for complete boxed warning.