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Leveraging the ubiquitin proteasome system for targeted therapy in Acute Myeloid Leukemia

This research proposal will investigate the role of protein degradation in acute myeloid leukemia (AML). Specifically, we will assess the function of…

Cardioprotective Strategies and Cardiotoxicity Prediction in Children with Acute Myeloid Leukemia

We seek to reduce the adverse cardiac effects of chemotherapy in pediatric AML patients. We are assessing markers of heart function and injury to comp…

Precision targeting of BFL-1 and MCL-1 in pediatric leukemias to overcome treatment resistance

Pediatric leukemia cells hijack the family signaling network to overexpress a range of proteins, including and , and thereby enforce cellular immor…

Identification of therapeutic targets sensitizing acute myeloid leukemia to BCL2 inhibitors

Venetoclax is a medication that can induce cell death of acute myeloid leukemia (AML), but its effectiveness needs to be further improved to benefit m…

Precision Targeting of Hairy Cell Leukemia using Chimeric Antigen Receptor T cells

<p>Though effective treatments in hairy cell leukemia and variant (HCLv) exist, they are associated with profound immunosuppression; thus, more …

Synergistic targeting of metabolic and epigenetic vulnerabilities in leukemia stem cells

Our lab is focused on identifying unique features that distinguishes acute myeloid leukemia (AML) stem cells from normal stem cells. The cells that m…

Chronic myeloid leukemia (CML) diagnosis

To diagnose CML, doctors use a variety of tests to analyze blood and bone marrow cells.

Improving the outcomes of young Black adults diagnosed with acute myeloid leukemia

Young Black patients diagnosed with acute myeloid leukemia (AML) have significantly shorter survival compared to White patients. To comprehensively as…

Identifying Mechanisms of Chemoresistance Induced by MECOM in Primary-Refractory Acute Myeloid Leukemia

Approximately % of Acute Myeloid Leukemia (AML) patients are “” () and fail to go into remission with intensive induction chemotherapy. These patients…

Targeting kinase-dependent dysregulation of transcription factor control in acute myeloid leukemia

Defining mechanisms of dysregulated gene control are central to understanding cancer and the development of effective therapies. Our research is focus…

Modeling the Initiation and Progression of Down Syndrome Associated Leukemia using CRISPR/Cas9 at Single Cell Resolution

Children with Down syndrome (Trisomy ) have an increased risk of childhood leukemia and, in these cases, the initiating genetic alterations already oc…

Dissecting the heterogeneity of leukemic and pre-leukemic clonal expansion to identify genes associated with leukemia relapse and genesis

My research investigates the heterogeneity of leukemic and clonal expansion to identify genes associated with leukemia relapse and genesis. Contrary …

The Leukemia & Lymphoma Society® is now Blood Cancer United®

Today, The Leukemia & Lymphoma Society—now Blood Cancer United—unveiled its first national advertising campaign in more than a decade.

Personalized Anti-TCRVbeta2 therapeutic antibody and ADC for T Cell Leukemias and Lymphomas

T cell cancers together comprise ~% of acute leukemias and 's lymphomas. A major challenge with currently available treatments for these is that the t…

Precision Targeting of Metabolism and Mitochondria for Chemotherapy Resistance in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous group of diseases that require complex therapy and are difficult to cure. AML is caused by the accumu…

Booklet Updates - Leukemia

Leukemia Cup Regatta

Leukemia Golf Classic

More information coming soon...

A phase 1b/2 study targeting apoptotic and signaling pathways in T-acute lymphoblastic leukemia

lymphoblastic leukemia () is an aggressive leukemia with limited treatment options after chemotherapy. Our preclinical work in animal models of demo…

The Leukemia & Lymphoma Society and Blood Cancer UK Team Up to Award $4.25M for Research into Ways to Prevent Leukemia

RYE BROOK, N.Y., February , — The Leukemia & Lymphoma Society (LLS) and Blood Cancer UK announced today a , $. million grant to launch a research pro…

Deciphering the interplay between apoptotic and signaling pathways to target T-lineage acute lymphoblastic leukemia

is an aggressive leukemia with limited treatment options. cells resist to dying by suppressing their suicide pathways. BH3 mimetics reactivate the su…

Targeting immune checkpoint protein B7-H3 (CD276) in acute myeloid leukemia

We found that immune checkpoint protein B7-H3 is overexpressed in Acute Myeloid Leukemia (AML) cells compared to normal hematopoietic cells. We have d…

Improving CAR T-cell Therapy Efficacy in Acute Lymphoblastic Leukemia by Optimizing Design and Placement

Pediatric acute lymphoblastic leukemia (ALL) that is resistant to standard therapy is a challenge that has been partially overcome by therapy, yet re…

Chronic lymphocytic leukemia (CLL)

CLL is a blood cancer of the bone marrow that can progress quickly or slowly, depending on the form it takes.

Hairy cell leukemia (HCL)

HCL is a rare, type of blood cancer that starts in a B cell and gets its name from the short, thin projections that look like hair on its cells.