Search Results

Role of ERK isoforms in normal hematopoiesis and leukemia

Current therapies for cancers driven by “RAS/ERK’ pathway mutations, such as juvenile myelomonocytic leukemia (JMML), are either high risk (bone marro…

The Leukemia & Lymphoma Society 2025 Research Grants Include Acute Leukemia in Children with Down Syndrome

LLS has more than $ million research funding commitments to propel the next generation of blood cancer care Patient education, financial support and a…

Suggested Reading - Childhood Leukemia Guide for Families, Friends and Caregivers, 5th ed.

By Nancy Keene Childhood Cancer Guides, , pages ISBN: ---- This most complete parent guide provides accurate and understandable medical informat…

Studying the biology and therapeutic vulnerabilities of leukemia stem cells using AML-iPSCs

Acute myeloid leukemia (AML) is an aggressive blood cancer that still lacks effective therapies. Our goal is to identify therapeutic vulnerabilities f…

Mechanisms of oncogenic transcription in NPM1-mutant myeloid leukemia

NPM1-mutated leukemia is the most common AML in adult and characterized by upregulations of HOXA/B genes and MEIS1. Given the importance of oncogenic …

T cell acute lymphoblastic leukemia accumulation in the central nervous system

T cell acute lymphoblastic leukemia () has a strong tendency to infiltrate the central nervous system (CNS). The goal is hope to develop strategies to…

Lower Dose Mitoxantrone for Venetoclax Resistant Acute Myeloid Leukemia

regimens are the standard of care for many patients with acute myeloid leukemia (AML) and are highly active therapeutic strategies for this challengin…

Leukemia Research Funded by The Leukemia & Lymphoma Society Gets Infusion of Support from Startup Biotechnology Company

White Plains, NY - March , - A promising University of Michigan research project focused on developing new treatments for patients with a rare and le…

Acute myeloid leukemia (AML) diagnosis

Your doctor will usually order a series of blood and bone marrow tests to determine if you have AML and to diagnose your AML subtype.

Childhood acute myeloid leukemia (AML)

Because of new and better therapies, cancer survival rates for children with AML have improved dramatically during the last several decades.

Glycotyping as a novel approach to study leukemia stem cell heterogeneity and function

Leukemia stem cells (LSCs) are highly heterogeneous populations and key contributors to AML progression. Here, I aim to employ heparan sulfate (HS) gl…

Chronic lymphocytic leukemia (CLL) diagnosis

An accurate diagnosis for CLL is important in order to estimate the disease’s progression and determine the appropriate treatment.

Leukemia

Detection and Targeting of Enzymatic Base Editing Deregulation in Leukemia Stem Cells

Dr. Jamieson is examining the role of two enzymes (APOBEC3 and ADAR1) known to mutate DNA and RNA, and their role in acute myeloid leukemia (AML) and …

Leveraging p53 to Improve Menin Inhibition in Leukemia Therapy

This research investigates how the PRMT5-p53-DUSP6 axis regulates cytokine signaling in hematopoietic stem cells and its implications for AML (acute m…

Epigenetic heterogeneity in age-related clonal hematopoiesis and acute myeloid leukemia

Our focus is to unravel how clonal hematopoiesis (CH) progresses to leukemia. We will investigate how epigenetic heterogeneity affects Tet2-mutant hem…

Immunotherapy Study Funded by The Leukemia & Lymphoma Society Demonstrates Remarkable Results in Patients with Acute Lymphoblastic Leukemia

Contact: Andrea Greif() [email protected] Plains, NY (October , ) - Funding from The Leukemia & Lymphoma Society (LLS) over the past yea…

LLS PedAL: Precision Medicine for Children with Leukemia

As part of The LLS Children’s Initiative, LLS is working with a team of renowned pediatric oncologists to lay the groundwork for a global precision me…

Suggested Reading - My Journey with Leukemia: The Power of Family, Faith, and Humor

My Journey with Leukemia: The Power of Family, Faith, and Humor By Jennifer Venegas ​Published by Outskirts Press, , pages ISBN: ---- This book …

Targeting the interplay between signaling and transcriptional dysfunction in myeloid leukemias

Our research program is focused on understanding the intersection between signaling and transcriptional dysfunction in myeloid leukemias. We leverage …

Investigating the dependency for protein synthesis in Venetoclax/Azacitidine-resistant acute myeloid leukemia

Relapsed and/or refractory acute myeloid leukemia (AML) display resistance to Venetoclax and Azacitidine (Ven/Aza) with approximately one third of pat…

Interrogation of glutathione biology in relapsed acute myeloid leukemia stem cells

Acute myeloid leukemia (AML) is a devastating blood cancer. Most AML patients will initially respond to standard therapy; however, for many patients t…

Targeting Leukemia Stem Cells in the Clinical Setting: The Development of A Comprehensive Program

My focus is to develop a program in which novel therapies targeting leukemia stem cells (LSCs) are tested in clinical trials. This is achieved via par…

Kura Oncology’s Menin Inhibitor Ziftomenib Selected for The Leukemia & Lymphoma Society’s Pediatric Acute Leukemia (PedAL) Master Clinical Trial

SAN DIEGO, December , – Kura Oncology, Inc. (NASDAQ: KURA), a biopharmaceutical company committed to realizing the promise of precision medicines fo…

Chronic myeloid leukemia (CML) treatment

Treatment for CML differs depending on the phase of the CML.