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Targeting Microenvironment Determinants in Peripheral T-cell Lymphoma
Peripheral T-cell lymphomas are highly aggressive blood cancer that have very poor survival rate, highlighting the need for new therapies to improve p…
MPN Advocacy and Education International
To make a difference in the lives of those affected by myeloproliferative neoplasms. Offers disease, treatment and clinical trial information …
Lidia
I am still in treatment for leukemia, a diagnosis my mom was devastated to hear when I was just four years old.My dream is to meet Roman Reigns and te…
The impact of non-coding somatic mutations on the prognosis and progression of multiple myeloma
Past studies of protein-coding regions have extensively characterized the genome of multiple myeloma (MM), but there has been little information on th…
The role of FOXM1 downregulation in the development of clonal dominance in del(5q) MDS
Our research focuses on identifying the molecular mechanism underlying the development of a dominant population of abnormal stem cells in myelodysplas…
Identification of therapeutic targets sensitizing acute myeloid leukemia to BCL2 inhibitors
Venetoclax is a medication that can induce cell death of acute myeloid leukemia (AML), but its effectiveness needs to be further improved to benefit m…
T-cell immunotherapy for prevention of COVID-19 following bone marrow transplantation
SARS-Cov-2 infections may be prolonged in cancer patients and may enable intrahost development of virulent viral variants. Adoptive immunotherapy with…
Systematic multiomic profiling of tumor and immune cells for non invasive detection of early myeloma
Multiple myeloma remains largely incurable and there is consensus that the pathway to cure cancer involves treating patients earlier. Thus, there is a…
Improving therapy for CRLF2-rearranged Ph-like acute lymphoblastic leukemia
CRLF2-rearranged ALL is the most common subset of Ph-like ALL, has a very poor prognosis and lacks effective therapy. This project will use two novel …
Precision Targeting of Hairy Cell Leukemia using Chimeric Antigen Receptor T cells
<p>Though effective treatments in hairy cell leukemia and variant (HCLv) exist, they are associated with profound immunosuppression; thus, more …
Deciphering the interplay between apoptotic and signaling pathways to target T-lineage acute lymphoblastic leukemia
T-ALL is an aggressive leukemia with limited treatment options. T-ALL cells resist to dying by suppressing their suicide pathways. BH3 mimetics reacti…
Genomic interrogation of high-risk myeloid neoplasms to identify new therapies
The long-term goal of my research program is to improve the outcomes for patients with high-risk myeloid blood cancers, particularly those with loss o…
Inflammation-responsive mechanisms of malignant stem cell generation and eradication in multiple myeloma
The focus of my research is to elucidate the core molecular regulators of malignant stem cell generation in multiple myeloma. My approach addresses th…
Dorette
I was first told I had non-Hodgkin lymphoma at the age of 20. I had no idea what that was, I just knew it was a form of cancer and that there was a po…
Booklet Updates
The Leukemia & Lymphoma Society wants you to have the most up-to-date information about blood cancer treatment. See below for new treatments that have…
Elyssa
My daughter, Elyssa donated her hair for children with cancer only months before she herself was diagnosed with Hodgkins lymphoma. Upon her diagnosis,…
Bonnie
I went to the ER with chest pain in March of 2013 when my doctor saw a spot in my CAT scan the size of an orange. A few days later, I had a biopsy and…
Kay and David
As an 18-year breast cancer survivor, Kay was just starting to enjoy retirement in 2018 when she was diagnosed with mantle cell lymphoma. Even though …
Halley
My story with cancer began long before I was diagnosed this year at 33. When I was 4 years old, my 18-month-old sister, Hannah, became too tired to pl…
Ron
This started 11 years ago when my mom was first diagnosed with lymphoma. I wanted to do more and saw the purple team always out running events I was e…
Graham
In the fall of 2008, my wife and I got married. Shortly after returning from our honeymoon, I began developing pains and weakness in my joints. This c…
Prevention of antigen escape by modulation of off-target tumor killing in T cells
T-cell mediated therapies are all impeded by the same cause- tumoral antigen (Ag) escape: rare Ag– cells in tumors survive the initial attack and lead…
Suggested Reading - On the Road to Remission
On the Road to Remission by Keith D. GuernseyIndependently Published, 2020, 60 Pages, Paperback and KindleISBN: 978-8581881767Join us as Keith D. Guer…
Preventing follicular lymphoma progression and transformation through precision therapy
Follicular lymphomas (FL) depend on stromal cells for survival and proliferation and evade T-cell immune surveillance. Although indolent, most FLs eve…
Understanding the mechanisms and developing novel therapies for a high-risk DLBCL population
The most aggressive forms of DLBCL are marked by alterations that result in MYC and BCL2/6 activation. In cases without genetic alterations at these l…