1548 results for Leukemia
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Lidia
I am still in treatment for leukemia, a diagnosis my mom was devastated to hear when I was just four years old.My dream is to meet Roman Reigns and te…
Impaired dynamic nucleosome remodeling as a leukemogenic mechanism and therapeutic target in AML
The cohesin and BAF complexes are both epigenetic regulators of dynamic chromatin accessibility. Recurrent mutations are observed in proteins of both …
CLL Patient Databases
Maintains information on a large number of patients with chronic lymphocytic leukemia to contribute to medical research about its diagnosis, prognosis…
Laila
Laila was diagnosed with acute lymphoblastic leukemia (ALL) three months after her second birthday. She is the only girl and her three older brothers …
Mary Kay
Hello, my name is Mary Kay Hettick. I've always thought I was in good health until, in October when I was diagnosed with acute myeloid leukemia (AML)…
Javier
Javier was diagnosed with pre b ALL leukemia in October . He was in and out of the hospital for over a year and he has been through a lot.Javier is so…
Uncovering MGA-driven epigenetic reprogramming in Richter's syndrome
Richter’s syndrome (RS) is a critical complication of chronic lymphocytic leukemia. RS patients are refractory to most existing therapies and show a m…
Research: Grants
Novel targeted therapies for acute myeloid leukaemia and multiple myeloma
Outcomes for acute myeloid leukemia (AML) and multiple myeloma (MM) patients remain inadequate and new treatment options to combat resistance against …
Targeting the pathogenic 'fire triangle' of inflammation, metabolism and mutations in myeloid leukemogenesis
My lab is focused on understanding the pathogenic interplay between oncogenic mutations, chronic inflammation and aberrant metabolism as a driver of t…
Targeting metabolic reprogramming in MDS and AML stem/progenitor cells
Myelodysplastic neoplasms are malignant disorders driven by expansion of diseased hematopoietic stem cells and progression to leukemia. Our investigat…
The role of Plek2 in the pathogenesis of myeloproliferative neoplasms
Our research focuses on the study of a novel therapeutic target, named Plek2, in the development of myeloproliferative neoplasms (MPNs). MPNs can prog…
Blood Cancer United Responds to Federal Funding Crisis with $8 Million Gift from Big Nova Foundation
Blood Cancer United, formerly The Leukemia & Lymphoma Society, today announced a transformative $ million gift from the Big Nova Foundation. This com…
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Karrah
I was first diagnosed with acute lymphoblastic leukemia (ALL) in June of . Like a whirlwind, I spent the next nine months fighting for my life, battl…
John
After six months of frequent hospital and doctor visits for unexplained fever, weakness, and changes in John's activity and personality, an ultimatum …
Bethany
I was , married for two years, and my husband and I had just celebrated our anniversary at my business, Gigi’s Cupcakes. But on March , , that all ch…
Christa
I was diagnosed with acute lymphoblastic leukemia (ALL) at three years old. I experienced two and a half years of chemotherapy, lumbar punctures, bloo…
Brian
Brian Shaw (a.k.a. “Little Man”) is an energetic, happy, intelligent and compassionate boy. For nearly a year, starting when he was four, several of …
Mantle Cell Lymphoma Video Vignettes for Healthcare Professionals
Developed through a collaboration between The Leukemia & Lymphoma Society & The Association of Cancer Care Centers.This video series provides an overv…
Education Resources
Evaluating a novel collaboration between NOTCH1 and MLL1 for improved targeted treatments in T-ALL
Most T cell acute lymphoblastic leukemia () patients respond to chemotherapy, however many relapse with limited therapy options. To address this probl…
Leveraging dysregulated signaling networks for therapeutic benefit in myeloproliferative neoplasms
The objective of this project is to decipher mechanisms driving transformation of myeloproliferative neoplasms (MPNs) to secondary acute leukemia (sAM…
A novel BAFF CAR-T for treatment of HCL
Despite the success of Chimeric antigen receptor T cell () immunotherapies, disease relapse occurs in a majority of patients. We have developed a nove…
Optimizing MICA/B antibody for AML by selective binding to Fc activating receptors
Acute myeloid leukemia (AML) is a blood cancer characterized by poor clinical outcomes. We developed an antibody that inhibits AML in models by trigge…
“Open-Surfaceomics” for Identifying Novel Surface PTMs as Immunotherapy Targets in AML
A lack of highly selective surface antigens for Acute Myeloid Leukemia (AML) immunotherapy is a major bottleneck in the development of both CAR T cell…
TCR T cells for the treatment of SRSF2 mutant myeloid neoplasms
Mutations in the RNA splicing factor gene SRSF2 occur in % of patients with MDS, % of patients with chronic myelomonocytic leukemia (CMML), and % of A…
Uncovering mechanisms of DNMT3A stability in hematologic malignancies
DNMT3A is a critical tumor suppressor in hematologic malignancies; DNMT3A protein levels affect both tumor latency and type. DNMT3A is regulated in pa…