1540 results for Leukemia
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Developing novel therapeutic approaches for classical and variant hairy cell leukemia
In this proposal, we have combined clinical and research expertise in HCL across Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College…
Targeting leukemia stem cells by disrupting translational fidelity
Dr. Signer is investigating how the process of building defective proteins (inaccurate protein synthesis) plays a role in the development of a type of…
Combination Targeted Therapy in Chronic Lymphocytic Leukemia
Targeted therapies have replaced chemoimmunotherapy in chronic lymphocytic leukemia (CLL). We previously reported that combined BTK inhibitor (ibrutin…
Discovering the function and targeting dysregulated nuclear condensates in myeloid leukemia
Although molecular targeted therapy has dramatically changed how we treat cancer, the treatment for acute myeloid leukemia (AML) remains focused on th…
CEBPA mutations in the pathogenesis of leukemia
mutations affecting the basic leucine zipper (bZIP) domain of C/EBPα characterize a distinct subset of acute myeloid leukemia with relatively favorabl…
Molecular basis and new therapeutic strategies in lineage ambiguous leukemia
leukemias are blood cancers with unclear biologic basis and suboptimal treatment options. Here, I will identify the cell of origin of lineage ambiguo…
Initiation of a novel immunotherapeutic to safely eradicate acute leukemia
We propose to develop a novel personalized immunotherapy to treat patients with refractory acute myeloid leukemia. We have shown that T cells () can …
Histone methyltransferases as key dependencies in SETBP1-mutant leukemias
This study aims to explore how mutant SETBP1 affects histone methyltransferase complexes to drive gene transcription. I will use biochemical, imaging…
Dissecting the role of a key epigenetic modulator in Mixed Lineage Leukemia
We study how a protein called Dpy30 controls blood cancers by regulating chromatin, the physical structure where our genes reside. We study how this p…
Precision Medicine Inhibitor and Immunotherapy Approaches for High-Risk Childhood Leukemias
Dr Tasian’s scientific passion is successful development of precision medicine therapies for childhood leukemia. Her translational laboratory researc…
Suggested Reading - Adult Leukemia: A Comprehensive Guide for Patients and Families
Adult Leukemia: A Comprehensive Guide for Patients and Families By Barbara Lackritz O'Reilly & Associates Inc., , pages ISBN: This guide provi…
Suggested Reading - Adult Leukemia: A Comprehensive Guide for Patients and Families
Adult Leukemia: A Comprehensive Guide for Patients and Families By Barbara Lackritz O'Reilly & Associates Inc., , pages ISBN: This guide provi…
FDA Approves New Formulation of Important Childhood Leukemia Drug
The U.S. Food and Drug Administration yesterday approved nelarabine injection, a critical treatment for acute lymphoblastic leukemia (), an aggressiv…
Blood Cancer
Targeting mitochondrial dynamics in venetoclax-resistant acute myeloid leukemia
Although new targeted therapies have been discovered and approved for the treatment of various types of leukemia, in many cases patients do not respon…
Investigating and targeting the histone acetylation reader protein ENL in acute leukemias
Leukemia often results from aberrant gene expression caused by epigenetic alterations. Previously we discovered a novel histone acetylation reader dom…
Strategic combinations to overcome therapeutic resistance and relapse in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most fatal type of leukemia and has a high rate of relapse following current therapies. We have recently uncovered…
Investigating the molecular basis of mRNA processing in acute myeloid leukemia
Our research aims to discover key driving factors in leukemia that regulate mRNA processing. The proposed experiments utilize a combination of biochem…
ASH1L degradation as a new treatment for acute leukemia
This project is focused to develop small molecule degraders of ASH1L histone methyltransferase as a treatment for aggressive of AML and ALL with high…
New Targeted Therapies for Pediatric Acute Myeloid Leukemia
Our research focuses on the preclinical evaluation of new targeted therapies for subtypes of childhood AML. We are deploying screening approaches to …
Immunotherapy Greatly Improves Survival for Infants with an Aggressive Form of Leukemia
These results mark a big step forward in the treatment of infants with this form of Acute Lymphoblastic Leukemia (ALL).
News Release
Affinity-Tuned T-Cell Engagers for Dual Targeting of B-Myeloid Mixed Phenotype Acute Leukemia
Our objective is to develop a highly specific engaging therapy to treat a subtype of leukemia that currently lacks effective treatment. We also aim t…
211Astatine-CD123 Radioimmunotherapy for Cancer (Stem) Cell-Directed Treatment of Acute Leukemia
Because acute leukemias are very sensitive to radiation, radioisotopes are ideal payloads to arm antibodies against these , aggressive blood cancers. …
Chronic myeloid leukemia (CML) signs and symptoms
People who have chronic myeloid leukemia (CML) may not have any symptoms at first. Often, patients learn they have CML after a routine physical exam o…
Blood Cancer
Understanding the role of Metabolic Regulator SIRT5 in Acute Lymphoblastic Leukemia
p>SIRT5 is a master regulator of central energy metabolism. The survival and growth of Acute Myeloid Leukemia (AML) cells depend on SIRT5. I will e…
Improving BTK Inhibitor Therapy in Chronic Lymphocytic Leukemia Through Rational Combination Strategies
Ibrutinib is a targeted oral treatment for CLL that is safe and highly effective, however it must be given indefinitely which leads to chronic side ef…