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Investigating the dependency for protein synthesis in Venetoclax/Azacitidine-resistant acute myeloid leukemia
Relapsed and/or refractory acute myeloid leukemia (AML) display resistance to Venetoclax and Azacitidine (Ven/Aza) with approximately one third of pat…
Ukonnaya
Our son was diagnosed with acute myeloid leukemia (AML) at months, and our world changed dramatically. We had a daughter and a - daughter for whom l…
Stories
Lipid-dependent regulation of oncogenic signaling in DLBCL growth and therapeutic response
Certain genetic alterations in Diffuse Large B Cell Lymphomas (DLBCL) render these tumors highly aggressive. Aggressive DLBCLs may also form secondary…
Association of Oncology Social Work
To advance excellence in the psychosocial care of persons with cancer, their families, and caregivers through: networking ,education , advocacy, resea…
Triage Cancer
To provide free education on legal and practical issues that may impact individuals diagnosed with cancer and caregivers, through events, materials, a…
Laila
Laila was diagnosed with acute lymphoblastic leukemia (ALL) three months after her second birthday. She is the only girl and her three older brothers …
Suggested Reading-What Happens When Someone I Love Has Cancer
Join Mia and her stuffed giraffe Stuart as they explain the science of cancer and how a loved one's diagnosis and treatment affects a kid's life. The…
Booklet Updates
Blood Cancer United wants you to have the most information about blood cancer treatment. See below for new treatments that have been FDA approved sin…
Chris
Chris is a retired Army colonel. He graduated from Temple University and set into life at home with his family when he was diagnosed with a hernia. In…
The Role of the DNA Sensor AIM2 in B Cell Fate and Function After HCT
Altered B cell homeostasis plays a key role in the development of chronic (cGVHD) after hematopoietic stem cell transplantation (HCT). We hypothesize…
Genomics of Diffuse Large B Cell Lymphoma: pervasive role of super-enhancer hypermutation in dysregulating oncogene expression
We recently identified a pervasive, pathogenically relevant mutational mechanism that targets (SE) in DLBCL, leading to target gene deregulation. Her…
TCR-like CARs targeting GvL mHAgs for the treatment of post-transplant AML relapse
AML recurrence is a devastating event after . I hypothesize that it could be counteracted through targeting of mHAgs via CARs. I will identify scFVs…
Research: Grants
Lia
My dad, Arthur, and I were super close my entire life. He was always my person. He was diagnosed with chronic myeloid leukemia (CML) that converted to…
Stories
CEBPA mutations in the pathogenesis of leukemia
mutations affecting the basic leucine zipper (bZIP) domain of C/EBPα characterize a distinct subset of acute myeloid leukemia with relatively favorabl…
Leveraging the ubiquitin proteasome system for targeted therapy in Acute Myeloid Leukemia
This research proposal will investigate the role of protein degradation in acute myeloid leukemia (AML). Specifically, we will assess the function of…
The Adventures of Peighten and Gingerbread
Based on the relationship between the author & licensed therapist’s daughter, Peighten, & her late grandmother, who passed away after her battle with …
American Society for Reproductive Medicine (ASRM)
ASRM is a multidisciplinary organization dedicated to the advancement of the art, science and practice of reproductive medicine. The Society accomplis…
Targeting the MMP-13/PD-1H signaling axis for multiple myeloma bone disease and immunosuppression
Multiple myeloma is an incurable blood cancer complicated by bone diseases and compromised immune system. Our work indicated that checkpoint inhibitor…
A Phase I/II Study of the Combination of ALX148, Rituximab and Lenalidomide in Patients with Indolent and Aggressive B-cell Non-Hodgkin Lymphoma
SIRPα+ macrophages mediate resistance to lenalidomide in lymphoma, limiting the activity of immunotherapy for these patients. Therefore, we propose a…
Niclosamide for the Treatment of Relapsed/Refractory Pediatric Acute Myeloid Leukemia
Niclosamide is an FDA approved drug that is well tolerated and acts synergistically with chemotherapy to kill AML cells. We will conduct a Phase I cl…
Clinical and molecular determinants of CLL eradication with targeted combination therapy
The genomic architecture of residual CLL and molecular determinants of disease progression after targeted combination therapy are unknown. In a phase …
Characterization and Targeting of Tumor-Associated Monocytes/ Macrophages that Limit the Efficacy of PD-1 Blockade in Lymphoma
Inhibition of the exhaustion pathway enables the immune system to attack cancers. blockade is now a standard treatment for relapsed classic Hodgkin …
CD70-directed CAR T-cell therapy for the treatment of relapsed/refractory pediatric AML
In this project, we will test an innovative therapy called CAR therapy for children with a type of cancer called AML. In the laboratory, we have iden…
Suggested Reading - Beyond the Diagnosis: Surviving and Thriving with Multiple Myeloma and Breast Cancer
"Beyond the Diagnosis: Surviving and Thriving with Multiple Myeloma and Breast Cancer" unfolds an inspiring narrative that transcends the boundaries o…
Suggested Reading - Brain Tumors - Leaving the Garden of Eden
This is a survival guide to diagnosis, learning the basics, getting organized and finding your medical team, was written specifically for patients and…