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Exploiting Novel Therapeutic Vulnerabilities in Chronic Myelomonocytic Leukemia
The overall objective of this project is to identify novel pathways that may be targeted for therapeutic benefit in CMML. We have identified abnormal …
Dr. Brown
Dr. Jennifer Brown, Ph.D., who played a role in advancing ibrutinib for patients with chronic lymphocytic leukemia (CLL), is the recipient of an LLS T…
Social Security Disability Help
To inform people on how to navigate the process of applying for Social Security Disability benefits Provides information to individuals who are …
Identifying Mechanisms of Chemoresistance Induced by MECOM in Primary-Refractory Acute Myeloid Leukemia
Approximately % of Acute Myeloid Leukemia (AML) patients are “” () and fail to go into remission with intensive induction chemotherapy. These patients…
Leveraging the ubiquitin proteasome system for targeted therapy in Acute Myeloid Leukemia
This research proposal will investigate the role of protein degradation in acute myeloid leukemia (AML). Specifically, we will assess the function of…
BRAF inhibition as an alternative to chemotherapy in the treatment strategy of hairy cell leukemia
Hairy cell leukemia (HCL) is very sensitive to chemotherapy, whose toxicity to the bone marrow and the immune system is however concerning. We have es…
Procarbazine
Generic name Procarbazine Pronunciation Brand name(s), other common name(s) Matulane® Drug type …
Targeting SF3B1 splicing factor mutant myeloid malignancies through dependency on GPATCH8
Mutations in RNA splicing factors, particularly those involving the core splicing factor SF3B1 are amongst the most common mutations found in myeloid …
Targeting the cell surface U5 snRNP complex as a novel immunotherapy for AML
A major limitation of immunotherapy approaches for AML has been the lack of known targetable cell surface antigens specific to AML cells. This project…
Dissecting the mitochondrial alterations by aberrant NPM1 to the pathogenesis of myelodysplastic syndrome
Survival rates for those afflicted with MDS have not improved despite extensive effort to identify the key genetic events in its pathogenesis. This pr…
Children’s Leukemia Research Association (CLRA)
To support research efforts towards finding the causes and cure for leukemia. Patient Aid Program offers limited funds (up to $, per year) to as…
Miracle Flights
To provide free commercial flights to those in need of medical care, far from home. Provides free, air transportation for medical care via co…
A Polyomic Approach to Chronic Graft-versus-Host Disease (cGvHD) Biomarkers in Adults
Our team is the first to develop a polyomic pediatric cGvHD biomarker test for assessing the risk of developing cGvHD. A cooperative adult phase III c…
Relevance of ubiquitin dependent proteolysis in diffuse large B-cell lymphoma
The goal of this proposal is to investigate the significance of genes of the ubiquitin proteasome system (UPS) that are mutated in Diffuse Large Lymp…
RemediChain
RemediChain accepts donations of unopened, unexpired oral medicines and matches those donations with vulnerable patients in need.Program is free for a…
Targeting mutant IDH2 in angioimmunoblastic T-cell lymphoma
Angioimmunoblastic lymphoma is a rare, aggressive form of lymphoma associated with poor clinical outcomes in response to current therapeutic approac…
Exploiting escape from Y-inactivation as a synthetic dependency in MYC-driven lymphoma
As a lymphoma develops it expresses genes that are normally silenced to convey a survival advantage. When these genes are on the X or Y (sex chromosom…
Functionalizing novel PHIP variants in ancestry-specific acute myeloid leukemia
AML risk stratification established by previous studies do not reflect survival outcomes observed in Black patients. Exome sequencing of Black AML pa…
Taylor
Meet Taylor Carol. survivor to singer. Taylor started singing in the 4th grade, until he was diagnosed with acute lymphoblastic leukemia at just year…
CenterWatch
CenterWatch is a source of clinical trials information for patients, caregivers and clinical research professionals. Offers online tools to: …
Get Palliative Care
To increase the availability of quality palliative care services for all people living with serious illness. Provides information about palliat…
Hole in the Wall Gang Camp
To ensure that every child with a serious medical condition has the chance to experience the world of possibilities that camp has to offer; to provide…
Targeting Siglec15 to promote immune response to malignant B cells
The goal of this project is to explore a novel immunologic therapeutic target for hematologic malignancies, SIGLEC15 (Sig15). The central hypothesis i…
Suggested Reading - Hundred Percent Chance
Hundred Percent Chance: A Memoir is a raw and realistic memoir about a young college student who was diagnosed with Acute Myeloid Leukemia in while h…
Targeting Unmet Needs For B-cell Lymphomas
Over the past year, we explored whether there is a biological basis that helps explain why African and African American patients typically present wit…