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Eryn
I was diagnosed at years old with acute lymphoblastic leukemia (ALL) and went into remission when I was . I spent two years at Wilford Hall, where I …
Chris
On October , , at : p.m., Stacey left. Those are numbers I will always know without thinking. We went to UC General on the morning of September , as s…
Stories
Lisa
I lost my big brother, Vincent J. Di Cristo, to two forms of cancer on February , . He apparently had both lymphoma as well as Burkitt lymphoma. I’…
Tessa
Tessa surprised our family when she came rockin' an extra chromosome. She spent days in the NICU and left with oxygen but seemed in good health other…
Novel Immunotherapy Combinations in Relapsed, Refractory Mantle Cell Lymphoma
We are evaluating two parallel clinical trials with synergistic immunotherapies in mantle cell lymphoma (MCL), including ) tafasitamab and lenalidomid…
Spatial architecture and malignant cell characterization of nodular lymphocyte-predominant Hodgkin lymphoma
Nodular Hodgkin lymphoma is recognized as a disease entity in a spectrum of related diseases, including rich lymphoma. Although treatments are gene…
Identifying Mechanisms of Chemoresistance Induced by MECOM in Primary-Refractory Acute Myeloid Leukemia
Approximately % of Acute Myeloid Leukemia (AML) patients are “” () and fail to go into remission with intensive induction chemotherapy. These patients…
How does loss of chromosome Y perturb blood cell biology and create therapeutic vulnerabilities in acute myeloid leukemia?
Loss of chromosome Y (LOY) is common in acute myeloid leukemia (AML) yet the mechanistic and therapeutic roles of LOY remain largely unexplored. Using…
Personalized Anti-TCRVbeta2 therapeutic antibody and ADC for T Cell Leukemias and Lymphomas
T cell cancers together comprise ~% of acute leukemias and 's lymphomas. A major challenge with currently available treatments for these is that the t…
Understanding the clonal origin, evolution, and progression of myeloid malignancies
The overarching focus of my research is to understand the clonal origin, evolution, and progression of myeloid malignancies and biological and clinica…
Analysis and therapeutic targeting of the immune regulatory and ubiquitination pathways in Anaplastic Large Cell Lymphoma and Hodgkin Lymphoma
My lab is focused on the immune regulatory mechanisms and machinery in lymphoma. We have established multiple screening technologies and animal mode…
TCR-directed immunotoxins and antibody drug conjugates for the treatment of T cell malignancies
Few treatment options are available for T cell leukemias and lymphomas, collectively called T cell cancers that affect ~, patients worldwide each year…
Therapeutically actionable molecular safeguards in leukemic stem cells
Our research program’s goal is to identify therapeutically actionable pathways in and leukemic stem cells in myeloid malignancies. We specifically di…
Developing selective inhibitors of the b-catenin/BCL9 transcriptional complex for myeloma therapy
The /BCL9 transcriptional complex, is a novel dependency in multiple myeloma (MM). Disruption of this complex inhibits MM cell growth in culture and i…
Suggested Reading - Chicken Soup for the Surviving Soul: 101 Healing Stories About Those Who Have Survived Cancer
More than cancer survivors share their personal stories in this touching new collection of Chicken Soup. These heartwarming accounts of courageous pe…
A Kid Again
To provide free adventures that allows children with conditions to feel like A Kid Again. Provides a community of other families navigating l…
National Hospice and Palliative Care Organization (NHPCO)
To lead and mobilize social change for improved care at the end of life. Membership organization representing hospice and palliative care progra…
Happiness is Camping
To provide children with cancer and their siblings a traditional residential camp experience together with sophisticated medical care for campers both…
Skylar
As a parent, there are few words that can knock you on your feet. “Your child has cancer” is one of those phrases that can make you fall apart in an i…
Kayleen
On March , , our world changed forever.I was at work when I got the call from my husband that I was to meet him and Kayleen at Children’s Hospital in …
Jim
My brother Jim was an amazing man. He was a person for whom family was everything. He ran a plumbing business with his brothers and took pride in its …
Immune-Onc Therapeutics
In , LLS made an equity investment in Therapeutics. is a cancer immunotherapy company dedicated to the discovery and development of novel myeloid c…
Owen
On June , , I competed in my very first Ironman triathlon. After six months of dedicated training, I pushed through feeling a bit sick and crossed the…
Nancy
My first diagnosis was in when I got the news I had stage lymphoma. I went through chemo and radiation for this. years later I was diagnosed again …
Stories
Targeting Myeloid Malignancies through IRAK4 Synthetic Lethality Dependencies
Based on our preliminary data, we hypothesize that IRAK4 inhibition leads to LSPC reprogramming in MDS and AML. Aim will evaluate the mechanism by wh…