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Jennifer Woyach

The Ohio State University

Columbus, OH
United States

Overcoming BTK Inhibitor Resistance in Chronic Lymphocytic Leukemia

Coming soon.

Program: Career Development Program

Project Term: April 1, 2021 - March 21, 2026

Photo of Grant Recipient Jae Park

Jae Park

Sloan Kettering Institute for Cancer Research

New York, NY
United States

Developing novel therapeutic approaches for classical and variant hairy cell leukemia

In this proposal, we have combined clinical and research expertise in HCL across Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, the University of Pennsylvania, and Yale University to develop newer targeted therapeutics for every stage and subtype of hairy cell leukemia. Capitalizing on this combined expertise, our proposal stands to significantly advance treatment strategies for hairy cell leukemia through the following aims: to test BRAF inhibition for initial treatment of classical hairy cell leukemia, test new oral inhibitors of the MAP kinase signaling pathway known as ERK inhibitors in both classical and variant hairy cell leukemia, evaluate totally new treatments that degrade BRAF, and develop T-cell immunotherapies for the first time in hairy cell leukemia.

Program: Hairy Cell Leukemia Research Initiative

Project Term: October 1, 2021 - September 30, 2026