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Chronic myelomonocytic leukemia (CMML) signs and symptoms

Chronic myelomonocytic leukemia (CMML) signs and symptoms vary from patient to patient and depend on the type of CMML.  

Signs and symptoms of chronic myelomonocytic leukemia (CMML)

Those with a myelodysplastic subtype (MD-CMML) tend to present with low blood cell counts. Signs and symptoms may include: 

  • Weakness and fatigue due to anemia (a condition in which blood lacks adequate healthy red blood cells to carry sufficient oxygen throughout the body)
  • Petechiae (pinhead-sized sites of bleeding in the skin), bruising, and bleeding due to thrombocytopenia (low platelet counts)
  • Recurrent infections due to leukopenia (a below-normal white blood cell count) 

Patients with a myeloproliferative subtype (MP-CMML) tend to have high blood cell counts. Signs and symptoms may include: 

  • Enlargement of the spleen and liver
  • A feeling of fullness below the ribs due to spleen enlargement
  • Fatigue
  • Drenching night sweats
  • Bone pain
  • Weight loss

The signs and symptoms of CMML are common to other, less serious illnesses. However, if you're troubled by any of the above symptoms, see your doctor.

Learn more about communicating with your blood cancer specialist or find a list of suggested questions to ask your healthcare providers.  

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multiple myeloma (MM) and chronic myelomonocytic leukemia (CMML)

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