Ziftomenib

Ziftomenib can cause serious side effects, including:

• Differentiation Syndrome. Differentiation syndrome is a condition that affects your blood cells and can be life-threatening or lead to death if not treated. Differentiation syndrome can happen as early as 3 days after you start ziftomenib treatment and can also happen later during treatment. Tell your healthcare provider or go to the nearest hospital emergency room right away if you develop any of the following signs or symptoms:
• Fever, joint or bone pain, dizziness, shortness of breath or trouble breathing, cough, chest pain, rapid weight gain, rash, decreased urine output, swelling of hands, feet, ankles, or legs.
• QT prolongation. Changes in the electrical activity of your heart may lead to irregular heartbeats (rhythm) that can be life-threatening or lead to death. Tell your healthcare provider right away if you feel faint, lightheaded, or dizzy, or if you have shortness of breath, or if you feel your heart beating irregularly or fast during treatment.

The most common side effects of ziftomenib include: infections including bacterial infections, bleeding, diarrhea, nausea, feeling tired, swelling in the arms and legs, muscle, bone, and joint pain, itching, fever with decreased white blood cell counts, changes in liver function tests. Ziftomenib may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.