Topotecan

Black, tarry stools; blood in urine or stools; cough or hoarseness (accompanied by fever or chills); fever or chills; lower back or side pain (accompanied by fever or chills); painful or difficult urination (accompanied by fever or chills); pinhead-sized red spots on skin or rash, hives and/or itching; shortness of breath, troubled breathing or fast or irregular breathing; unusual bleeding or bruising; large, hive-like swellings on the face, eyelids, mouth, lips and/or tongue; puffiness or swelling of the eyelids or around the eyes; tightness in chest or wheezing; unusual tiredness or weakness; changes in the skin color of the face.