Du Wei

My research is centered on pathophysiology of hematologic diseases such as bone marrow failure and leukemia, with specific focus on hematopoietic stem cell (HSC), DNA damage and immune response, and tumor microenvironment. I have been investigating HSC-BM niche interaction and HSC regeneration under conditions of injury and aging; and have identified functional interactions between certain factors implicated in cell proliferation, polarity, adhesion/migration, stem cell metabolism and aging. My work has led to 53 peer-reviewed scientific papers in high-impact scientific journals, including Blood, JCI, Nat Comm and Leukemia. I laid the groundwork for my long-term research by developing cell and animal models as well as effective assays for identifying mechanisms underlying critical hematological diseases as PI on several NIH- and private-funded grants. I am confident that both myself as a PI and my innovative research are highly competitive in future success in grants and publications.